Evidence map›Paper›PMID 31259318›Full record

ArticleACS pharmacology & translational science2019

mGlu

Zixiu Xiang, Xiaohui Lv, James Maksymetz, Branden J Stansley, Ayan Ghoshal, Rocco G Gogliotti, Colleen M Niswender, Craig W Lindsley, P Jeffrey Conn

Open access · bronzeAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Activating mGluBiological psychiatry · 2021
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zixiu XiangDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Xiaohui LvDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
James MaksymetzDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Branden J StansleyDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Ayan GhoshalDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Rocco G GogliottiDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery,Department of Chemistry, Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Vanderbilt University Medical Center · US

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUTTING, LAURIE E · 2015 to 2019
$7.1M
Normalizing E:I imbalance in Rett Syndrome by Modulation of Late Response GenesK01MH112983 · NIMH · VANDERBILT UNIVERSITY · PI GOGLIOTTI, ROCCO GEORGE · 2017 to 2020
$543k
NICHD NIH HHS U54 HD083211NIMH NIH HHS K01 MH112983
6 · The paper itself

Abstract

Metabotropic glutamate (mGlu) receptor type 5 (mGlu

Identifiers

PMID31259318
PMCPMC6591772
OpenAlexW2945443156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.