Evidence map›Paper›PMID 31259236›Full record

ArticleACS biomaterials science & engineering2018

Boronic acid copolymers for direct loading and acid-triggered release of Bis-T-23 in cultured podocytes.

Yilong Cheng, Gary W Liu, Ritika Jain, Jeffrey W Pippin, Stuart J Shankland, Suzie H Pun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yilong ChengPresent address, Department of Applied Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, No. 28 Xianning West Road, Xi'an, Shaanxi 710049, China.
Gary W LiuDepartment of Bioengineering and Molecular Engineering & Sciences Institute University of Washington, 3720 15th Ave NE Seattle, WA 98195, USA.
Ritika JainDepartment of Bioengineering and Molecular Engineering & Sciences Institute University of Washington, 3720 15th Ave NE Seattle, WA 98195, USA.
Jeffrey W PippinDepartment of Medicine, Division of Nephrology, School of Medicine, University of Washington, 750 Republican Street, E-179, Seattle, WA 98109, USA.
Stuart J ShanklandDepartment of Medicine, Division of Nephrology, School of Medicine, University of Washington, 750 Republican Street, E-179, Seattle, WA 98109, USA.
Suzie H PunDepartment of Bioengineering and Molecular Engineering & Sciences Institute University of Washington, 3720 15th Ave NE Seattle, WA 98195, USA.
University of Washington · US

Funding

Juxta-glomerular cells serve as glomerular epithelial cell progenitors in glomerular diseaseR01DK097598 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, WESSELY, OLIVER · 2014 to 2022
$5.2M
Reduced Glomerular Progenitors Impair Regeneration in Aged KidneyR01AG046231 · NIA · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2016 to 2020
$2.6M
Rebuilding the glomerular filtration barrier by regenerating adult podocytesUH3DK107343 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, ZHENG, YING · 2017 to 2019
$1.3M
Rebuilding the glomerular filtration barrier by regenerating adult podocytesUH2DK107343 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, ZHENG, YING · 2015 to 2016
$855k
Leica SP8 WWL Confocal MicroscopeS10OD016240 · OD · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 2014 to 2014
$581k
NIA NIH HHS R01 AG046231NIDDK NIH HHS R01 DK097598NIDDK NIH HHS UH2 DK107343NIDDK NIH HHS UH3 DK107343NIH HHS S10 OD016240
6 · The paper itself

Abstract

We report an acid-reversible linker for triggered release of Bis-T-23, an experimental small molecule drug for kidney disease treatment that restores podocyte morphology during disease. Bis-T-23 contains catechols, which form an acid-reversible, covalent boronate ester bond with boronic acids. We synthesized phenylboronic acid-containing polymers using reversible addition-fragmentation chain transfer polymerization that were able to directly load and solubilize Bis-T-23. Because of the reversibility of the boronic ester bond, drug was released in its native form in a pH-dependent manner. The polymers rapidly trafficked into acidic compartments and did not exhibit cytotoxicity, and polymer-drug conjugates successfully delivered Bis-T-23 into cultured podocytes.

Indexed as

Bis-T-23boronic aciddrug deliverypolymerstriggered release

Identifiers

PMID31259236
PMCPMC6599616
OpenAlexW2900727744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.