ReviewAsia-Pacific journal of oncology nursing
Radiation Fibrosis Syndrome: the Evergreen Menace of Radiation Therapy.
Review in Asia-Pacific journal of oncology nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04850170 (The Evaluation of Manual Therapy for the Prevention of Radiation-Induced Fibrosis in Patients With Head and Neck Cancer), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of Manual Therapy for the Prevention of Radiation-Induced Fibrosis in Patients With Head and Neck Cancer
Who cites it
21 citing papers in PubMed.
- Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology.American journal of clinical dermatology · 2026Review
- Evaluation of Treatment Modalities for Radiation Therapy-Induced Trismus, Considering the Timing and Adherence to Progress in Mouth Opening and Oral Health-Related Quality of Life: A Systematic Review.Patient preference and adherence · 2026Review
- Manual therapy considerations for adhesive capsulitis in the breast cancer population: a clinical perspective.The Journal of manual & manipulative therapy · 2025Article
- Drosophila melanogaster: an old and future ally to radiobiology.Journal of radiation research · 2025Review
- Relationship between fibrosis induced by preoperative chemoradiotherapy and real-time tissue elastography of internal anal sphincter.International journal of colorectal disease · 2025Article
- Review
- Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results.Cancer biology & therapy · 2024Article
- Exploring Extravasation in Cancer Patients.Cancers · 2024Review
- Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis.Advances in wound care · 2024Review
- Health Effects of Ionizing Radiation on the Human Body.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Comparison of Myocardial Perfusion Scintigraphy and Coronary Angiography Results in Breast Cancer Patients Treated with Radiotherapy.Current oncology (Toronto, Ont.) · 2023Article
- Overview of radiotherapy-induced chronic pain in childhood cancer survivors: A narrative review.Paediatric & neonatal pain · 2023Review
- Deferoxamine to Minimize Fibrosis During Radiation Therapy.Advances in wound care · 2022Article
- Radiation Fibrosis After Stereotactic Body Radiation Therapy for Osseous Metastases: A Case Report.Cureus · 2022Article
- Effects of Ultrafine Single-Nanometer Oxygen Bubbles on Radiation Sensitivity in a Tumor-Bearing Mouse Model.International journal of molecular sciences · 2022Article
- Spontaneous Tissue Expander Migration in an Irradiated Field: A Case Report.Plastic and reconstructive surgery. Global open · 2021Article
- The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins.Cells · 2021Review
- The Impact of Smoking, Alcohol Use, Recurrent Disease, and Age on the Development of Neck Fibrosis in Head and Neck Cancer Patients Following Radiation Therapy.Frontiers in oncology · 2021Article
- Sonographic Pearls for Imaging the Brachial Plexus and Its Pathologies.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis is a descriptive appellation referring to the obliteration of normal tissue components replaced by matrix and disorganized and varied collagen fibrils that result in the loss of organ function and frequent tissue contraction leading to death or significant deterioration in the quality of life. Radiation fibrosis syndrome (RFS) is a progressive fibrotic tissue sclerosis with various clinical symptoms in the irradiation field. It is usually a late complication of radiation therapy and may occur weeks or even years after treatment. It may affect the musculoskeletal, soft tissue, neural tissue, and cardiopulmonary systems. RFS is a serious and lifelong disorder that, nevertheless, may often be prevented when identified and rehabilitated early. Genetic factors likely play a significant role in the development of chronic fibrotic response to radiation injury that persists even after the initial insult is no longer present. Management of this syndrome is a complex process comprising medication, education, rehabilitation, and physical and occupational therapy. A bibliographical search was carried out in PubMed using the following keywords: "radiation fibrosis," "radiation fibrosis syndrome," and "radiation-induced fibrosis." We also reviewed the most relevant and recent series on the current management of RFS, and the reviewed data are discussed in this article. This review discusses the pathophysiology, evaluation, and treatment of neuromuscular, musculoskeletal, and functional disorders as late effects of radiation treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.