ArticleGlobal pediatric health2019
Initial Symptoms of Langerhans Cell Histiocytosis: A Case Series.
Article in Global pediatric health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Molecular Mutations in Histiocytosis: A Comprehensive Survey of Genetic Alterations.Molecular biotechnology · 2025Review
- Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases.The Journal of international medical research · 2022Article
- Langerhans cell histiocytosis: Case report and literature reviewBiomedica : revista del Instituto Nacional de Salud · 2021Review
- Giant skull vault defect in a child caused by Langerhans cell histiocytosis: the "calvaria-eating disease".Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cell histiocytosis (LCH) is a rare childhood hematopoietic disease, and hence, there are few reports summarizing the course leading to the diagnosis. We described the initial symptoms and the clinical course of LCH. We carried out a retrospective review of charts from a single medical center, and 21 patients with the diagnosis of LCH were enrolled. The initial symptoms of 16 cases were caused by bone lesions; of these cases, there were 8 instances of soft tissue swelling as the initial symptom (38%) and 8 instances of bone pain without swelling (38%). Among the cases of bone lesion, 4 of 6 cases of skull lesion were painless while all vertebral body lesions and long bone lesions were accompanied by pain. LCH bone lesions caused various symptoms depending on the site of the lesion and this makes the diagnosis difficult. A detailed physical examination and imaging studies are recommended for early diagnosis.
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