ArticleChild neurology open2019
Germinoma Mimicking Brain Inflammation: A Case Report.
Article in Child neurology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Bilateral extramidline involvement in intracranial germinoma: diagnostic lessons from a complex presentation.Arquivos de neuro-psiquiatria · 2026Article
- A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit.Radiology case reports · 2023Article
- Pituitary stalk thickening in patients under 18 years of age - the most common causes and diagnostic procedures.Pediatric endocrinology, diabetes, and metabolism · 2022Review
- Pituitary Stalk Thickening: Causes and Consequences. The Children's Memorial Health Institute Experience and Literature Review.Frontiers in endocrinology · 2022Review
- Ectopic Germinoma: A Delayed Diagnosis With Serial Magnetic Resonance Imaging Features.Cureus · 2021Article
- Chemoradiation induced multiple sclerosis-like demyelination.eNeurologicalSci · 2021Article
- Pineal Dysgerminoma: A Misleading Clinical Course With Potential Life-Threatening Consequences.Cureus · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors report a case of a germinoma of the brain in the child with symptoms restricted to central nervous system. Ten-year-old girl presented initially with sight deterioration, learning difficulties, abnormal behavior, polydipsia, and polyuria. Brain magnetic resonance examination revealed T2 hyperintensity of the corpus callosum, anterior commissure, and caudate nuclei. Brain biopsy revealed extensive macrophage infiltration. Given these results and positive antinuclear antibodies in the blood, immunosuppressive and immunomodulatory treatment was implemented but it was not effective. The patient developed progressive quadriparesis, sleep disturbances, and dementia. Second brain biopsy was performed and it revealed germinoma cells. Chemotherapy was administered, but the girl died due to disseminated intravascular coagulation syndrome. The reported case shows an unusual coexistence of germinoma with prominent inflammation in the brain and highlights the importance of brain biopsy in such complex cases.
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Registered trials
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