Evidence map›Paper›PMID 31259151›Full record

ArticleFrontiers in oncology2019

A Splice Site Variant of

Natalia V Bogdanova, Peter Schürmann, Yana Valova, Natalia Dubrowinskaja, Nurzhan Turmanov, Tatyana Yugay, Zura Essimsiitova, Elvira Mingazheva, Darya Prokofyeva, Marina Bermisheva and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Targeting CDKs in the RNAPII transcription cycle.Nature reviews. Drug discovery · 2026
    Review
  3. Article
  4. Article
  5. Cells · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Natalia V BogdanovaGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Peter SchürmannGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Yana ValovaGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Natalia DubrowinskajaGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Nurzhan TurmanovGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Tatyana YugayOncology Clinic of Almaty, Almaty, Kazakhstan.
Zura EssimsiitovaDepartment of Biology and Biotechnology, Kazakh State National University of Al-Farabi, Almaty, Kazakhstan.
Elvira MingazhevaGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Darya ProkofyevaDepartment of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
Marina BermishevaInstitute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.
Elza KhusnutdinovaDepartment of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hanover, Germany.
Medizinische Hochschule Hannover · DEUfa Institute of Chemistry · RUAl-Farabi Kazakh National University · KZBashkir State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDK12 is a member of the cyclin-dependent kinase family that acts as regulator of DNA damage response gene expression. A c.1047-2A>G splice site variant of the

Indexed as

breast carcinomachromosome breakage syndromeDNA double-strand break repairfounder mutationgenetic susceptibility

Identifiers

PMID31259151
PMCPMC6587039
OpenAlexW2952268465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.