Evidence map›Paper›PMID 31259091›Full record

ArticleTranslational vision science & technology2019

Reproducibility of Measurements of Retinal Structural Parameters Using Optical Coherence Tomography in Stargardt Disease.

Xiangrong Kong, Alexander Ho, Beatriz Munoz, Sheila West, Rupert W Strauss, Anamika Jha, Ann Ervin, Jeff Buzas, Mandeep Singh, Zhihong Hu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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  8. Structural evaluation in inherited retinal diseases.The British journal of ophthalmology · 2021
    Review
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Xiangrong KongWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Alexander HoDoheny Eye Institute, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Beatriz MunozWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Sheila WestWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Rupert W StraussWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Anamika JhaDoheny Eye Institute, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Ann ErvinWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Jeff BuzasDepartment of Statistics, University of Vermont, Burlington, VM, USA.
Mandeep SinghWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Zhihong HuDoheny Eye Institute, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Janet CheethamFoundation Fighting Blindness, Columbia, MD, USA.
Michael IpDoheny Eye Institute, David Geffen School of Medicine at University of California Los Angeles, CA, USA.
Hendrik P N SchollWilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USDoheny Eye Institute · USUniversity of California, Los Angeles · USFoundation Fighting Blindness · USUniversity College London · GBUniversity of Basel · CHUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the reproducibility of retinal measurements from optical coherence tomography (OCT) in

methodsThe international multicenter Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Study enrolled 259 STGD1 patients. OCT images were graded by the study reading center (RC). Semiautomatic segmentation with manual adjustments was used to segment the layers of retinal pigmentation epithelium, outer segments, inner segments (ISs), outer nuclear layer (ONL), inner retina, and the total retina (TR). The images were overlaid to the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. For each layer, the thickness and the intact area of the ETDRS central subfield, inner ring, and outer ring were recorded, respectively. A different set of RC graders regraded 30 independent ProgStar images to evaluate measurement reproducibility. Reproducibility was assessed graphically and using statistics including intraclass correlation (ICC) and relative absolute difference (RAD).

resultsAcross all layers, measurements of the ETDRS central subfield had low ICC and/or large RAD. The outer-ring region was not fully captured in some images. For inner ring, good reproducibility was observed for intact area in the IS (ICC = 0.99, RAD = 4%), thicknesses of the ONL (ICC = 0.93, RAD = 6%), and TR (ICC = 0.99, RAD = 1%).

conclusionsSTGD1's complex morphology made outer retina segmentation challenging. Measurements of the inner ring, including the intact area of IS (i.e., the ellipsoid zone [EZ]) and ONL and TR thicknesses, had good reproducibility and showed anatomical impairment. TRANSLATIONAL RELEVANCE: ONL and TR thicknesses and the EZ intact area in the ETDRS inner ring hold potential as structural endpoints for STGD1 trials. Structure-function relationships need to be further established.

Indexed as

inherited retinal degenerationoutcome measuresreliabilityrepeatabilitystructure parameters

Identifiers

PMID31259091
PMCPMC6590092
OpenAlexW2951067052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.