Discovering major opioid-related research themes over time: A text mining technique.

The recent health crisis concerning opioid overdose has prompted watershed levels of publications. This study explores how opioid-related research themes have changed since 2000, using a text mining technique. The textual data were obtained from PubMed, and the research periods were divided into three periods. While a few topics appear throughout each period, many new health problems emerged as opioid abuse problems magnified. Topics such as HIV, methadone maintenance treatment, and world health organization appear consistently but diminish over time, while topics like injecting drugs, neonatal abstinence syndrome, and public health concerns are rapidly increasing. Recent widespread opioid abuse problems led to new research topics, including prescription drug monitoring programs, veteran's health issue, posttraumatic stress disorder, HCV, opioid-related deaths, and emergency department visits. Examination of scholarly publications reveals that the expanded use of opioids worsened opioid abuse problems and accelerated the emergence of new health problems.