Evidence map›Paper›PMID 31258985›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2019

Lost in Translation: Diagnosis Records Show More Inaccuracies After Biopsy in Oncology Care EHRs.

Jose-Franck Diaz-Garelli, Roy Strowd, Brian J Wells, Tamjeed Ahmed, Rebecca Merrill, Umit Topaloglu

Abstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Electronic health record data quality assessment and tools: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2023
    Pooled it
  2. Digital Health Data Quality Issues: Systematic Review.Journal of medical Internet research · 2023
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Building Cancer Diagnosis Text to OncoTree Mapping Pipelines for Clinical Sequencing Data Integration and Curation.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
  11. Article
  12. Exploring the Hazards of Scaling Up Clinical Data Analyses: A Drug Side Effect Discovery Case Report.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jose-Franck Diaz-GarelliWake Forest Baptist Medical Center, Winston Salem, NC.
Roy StrowdWake Forest Baptist Medical Center, Winston Salem, NC.
Brian J WellsWake Forest Baptist Medical Center, Winston Salem, NC.
Tamjeed AhmedWake Forest Baptist Medical Center, Winston Salem, NC.
Rebecca MerrillWake Forest Baptist Medical Center, Winston Salem, NC.
Umit TopalogluWake Forest Baptist Medical Center, Winston Salem, NC.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Postdoctoral Research, Instruction, and Mentoring Experience (PRIME)K12GM102773 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HOWLETT, ALLYN C · 2013 to 2018
$2.6M
NCATS NIH HHS UL1 TR001420NCI NIH HHS P30 CA012197NIGMS NIH HHS K12 GM102773
6 · The paper itself

Abstract

The use of diagnosis (DX) data is crucial to secondary use of electronic health record (EHR) data, yet accessible structured DX data often lack in accuracy. DX descriptions associated with structured DX codes vary even after recording biopsy results; this may indicate poor data quality. We hypothesized that biopsy reports in cancer care charts do not improve intrinsic DX data quality. We analyzed DX data for a manually well-annotated cohort of patients with brain neoplasms. We built statistical models to predict the number of fully-accurate (i.e., correct neoplasm type and anatomical location) and inaccurate DX (i.e. type or location contradicts cohort data) descriptions. We found some evidence of statistically larger numbers of fully-accurate (RR=3.07, p=0.030) but stronger evidence of much larger numbers of inaccurate DX (RR=12.3, p=0.001 and RR=19.6, p<0.0001) after biopsy result recording. Still, 65.9% of all DX records were neither fully-accurate nor fully-inaccurate. These results suggest EHRs must be modified to support more reliable DX data recording and secondary use of EHR data.

Identifiers

PMID31258985
PMCPMC6568058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.