Evidence map›Paper›PMID 31258928›Full record

ArticleBMJ open sport & exercise medicine2019

Acute high-intensity aerobic exercise affects brain-derived neurotrophic factor in mild cognitive impairment: a randomised controlled study.

Kate E Devenney, Emer M Guinan, Áine M Kelly, Bibiana C Mota, Cathal Walsh, Marcel Olde Rikkert, Stefan Schneider, Brian Lawlor

Abstract read
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In one paragraph

Article in BMJ open sport & exercise medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kate E DevenneySchool of Medicine, Trinity College Dublin, University of Dublin, Dublin, Ireland.ORCID 0000-0002-1590-3611
Emer M GuinanSchool of Medicine, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Áine M KellyDepartment of Physiology, Trinity College Institute of Neuroscience, Dublin, Ireland.
Bibiana C MotaDepartment of Physiology, Trinity College Institute of Neuroscience, Dublin, Ireland.
Cathal WalshSchool of Computer Science and Statistics, Trinity College Dublin, Dublin, Ireland.
Marcel Olde RikkertGeriatrics, Radboud UMC, Nijmegen, The Netherlands.
Stefan SchneiderInstitute of Movement and Neurosciences, German Sport University Cologne, Köln, Germany.
Brian LawlorSchool of Medicine, Trinity College Dublin, University of Dublin, Dublin, Ireland.

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild cognitive impairment (MCI).

methodsParticipants were randomised to one of two testing schedules, completing either a standardised exercise test (group A) or a resting control condition (group B). Blood sampling and cognitive measures (visuospatial learning and memory, sustained attention and executive function) were collected at baseline (T1) and postintervention (T2). An additional measurement of study outcomes was collected after exercise (T3) in group B only.

results64 participants (female 53.2%, mean age 70.5±6.3 years) with MCI were recruited. From T1 to T2, serum BDNF (sBDNF) concentration increased in group A (n=35) (median (Md) 4564.61±IQR 5737.23 pg/mL to Md 5173.27±5997.54 pg/mL) and decreased in group B (Md 4593.74±9558.29 pg/mL to Md 3974.66±3668.22 pg/mL) (between-group difference p=0.024, effect size r=0.3). The control group made fewer errors on the sustained attention task compared with the exercise group (p=0.025). Measures of visuospatial learning and memory or executive function did not change significantly between groups.

conclusionThis study is the first to show that a short bout of high-intensity aerobic exercise increases peripheral sBDNF in a population with MCI. However, acute exercise did not improve cognitive performance.

Indexed as

ageingbloodbrainexerciseexercise physiology

Identifiers

PMID31258928
PMCPMC6563898

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.