Evidence map›Paper›PMID 31258923›Full record

ArticleGlobal mental health (Cambridge, England)2019

East African HIV care: depression and HIV outcomes.

S M Meffert, T C Neylan, C E McCulloch, L Maganga, Y Adamu, F Kiweewa, J Maswai, J Owuoth, C S Polyak, J A Ake and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global mental health (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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  11. Depression among people living with HIV at a district hospital in KwaZulu-Natal, South Africa.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

S M MeffertDepartment of Psychiatry, University of California, 401 Parnassus Avenue, San Francisco, CA, USA.
T C NeylanDepartment of Psychiatry, University of California, 4150 Clement St, San Francisco, CA, USA.
C E McCullochDivision of Biostatistics, Department of Epidemiology, University of California, 550 16th Street, San Francisco, CA, USA.
L MagangaMbeya Medical Research Centre, P.O. Box 2410, Hospital Hill Rd, Mbeya, Tanzania.
Y AdamuU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Abuja, Nigeria.
F KiweewaMakerere University-Walter Reed Project, Plot 42, Nakasero Road, P.O. Box 16524, Kampala, Uganda.
J MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
J OwuothU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
C S PolyakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
J A AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
V G ValcourDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
Walter Reed Army Institute of Research · USUniversity of California, San Francisco · USMakerere University Walter Reed Project · UGMbeya University of Science and Technology · TZUniversity Memory and Aging Center · US

Funding

Gender Based Violence and HIV Outcomes: Tracking and Treating Mental IllnessK23MH098767 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MEFFERT, SUSAN M. · 2014 to 2017
$1.1M
NIMH NIH HHS K23 MH098767
6 · The paper itself

Abstract

importanceDepression is a common co-morbidity for people living with HIV (PLWH) and is associated with elevated plasma HIV RNA levels. While depression correlates with deficits in antiretroviral (ARV) adherence, little data exist to inform the relationship between depression and HIV vial load more broadly.

objectiveTo examine the relationship between depression and viral load in the African Cohort Study (AFRICOS) independently of ARV adherence.

designPLWH in Kenya, Uganda and Tanzania underwent screening for depression using the Center for Epidemiologic Studies Depression Scale (CESD) upon enrollment at AFRICOS HIV care sites.

settingAFRICOS is an ongoing prospective longitudinal cohort study enrolling HIV-infected adults at HIV care centers including sites in Kenya, Tanzania and Uganda. These sites are administered by President's Emergency Plan For AIDS Relief programs.

participantsHIV+ individuals were eligible if they were at least 18 years old, receiving HIV care at the enrolling clinic and consented to data and specimen collection.

main outcome measureCESD.

resultsAmong 2307 participants, 18-25% met the CESD threshold for depression. Depression was associated with decreased ARV adherence (OR 0.59,

conclusionsPLWH had high prevalence of depression on the CESD. Diverse depression symptoms were independently associated with increases in viral load, underscoring the need for comprehensive treatment of depression.

Indexed as

DepressionHIVsub-Saharan Africa

Identifiers

PMID31258923
PMCPMC6582461
OpenAlexW2947757856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.