Observational studyBMJ open respiratory research2019
Early identification of severe community-acquired pneumonia: a retrospective observational study.
Observational study in BMJ open respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Applications of the Early Warning Score as an outcome measure: a systematic review of methodologies.BMJ health & care informatics · 2026Pooled it
- National Early Warning Score Does Not Accurately Predict Mortality for Patients With Infection Outside the Intensive Care Unit: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Evaluating the Predictive Potential of an AI-Driven Deep Learning Model for Pneumonia-Associated Sepsis.Journal of clinical medicine · 2026Article
- Comparison of CURB-65 and qSOFA scores in predicting outcomes in community-acquired pneumonia.Annals of medicine and surgery (2012) · 2026Article
- Predictors of ICU Length of Stay in Patients with Severe Pneumonia: A Six-Year Retrospective Cohort Study Focusing on Traditional Chinese Medicine Adjuvant Therapy.International journal of general medicine · 2026Article
- Lactate Dehydrogenase to Albumin Ratio as a Predictor of Severe Community-Acquired Pneumonia in Patients Aged 60 years and Above: A Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Trends in mortality due to acute myocardial infarction and pneumonia among older adults in the U.S.: a CDC wonder analysis (1999-2023).Frontiers in cardiovascular medicine · 2026Article
- Performance of risk prediction scores for severe pneumonia in patients with community-acquired pneumonia after organ transplantation.ERJ open research · 2025Article
- Prediction of risk factors of plastic bronchitis in children with severe Mycoplasma pneumoniae pneumonia.Biomedical engineering online · 2025Article
- Prehospital Performance of Five Early Warning Scores to Predict Long-Term Mortality in Patients with Suspected Respiratory Infections.Diagnostics (Basel, Switzerland) · 2025Article
- Demographic and regional trends of pneumonia mortality in the United States, 1999 to 2022.Scientific reports · 2025Article
- Comparative Effectiveness of CURB-65 and qSOFA Scores in Predicting Pneumonia Outcomes: A Systematic Review.Cureus · 2024Review
- Comparison of Wireless Continuous Axillary and Core Temperature Measurement after Major Surgery.Sensors (Basel, Switzerland) · 2024Article
- Diagnosis and Therapy of Community-Acquired Pneumonia in the Emergency Department: A Retrospective Observational Study and Medical Audit.Journal of clinical medicine · 2024Article
- The prognostic value of rapid risk scores among patients with community-acquired pneumonia : A retrospective cohort study.Wiener klinische Wochenschrift · 2023Article
- Predictors of Length of Stay, Rehospitalization and Mortality in Community-Acquired Pneumonia Patients: A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- Predictive value of platelet-related parameters combined with pneumonia severity index score for mortality rate of patients with severe pneumonia.African health sciences · 2023Article
- Utility of the New Early Warning Score (NEWS) in combination with the neutrophil-lymphocyte ratio for the prediction of prognosis in older patients with pneumonia.Family medicine and community health · 2023Article
- Clinical characteristics and severity prediction score of Adenovirus pneumonia in immunocompetent adult.PloS one · 2023Article
- N-myc and STAT interactor is a novel biomarker of severity in community-acquired pneumonia: a prospective study.Respiratory research · 2022Observational
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Background: Community-acquired pneumonia (CAP) is a leading cause of sepsis worldwide. Prompt identification of those at high risk of adverse outcomes improves survival by enabling early escalation of care. There are multiple severity assessment tools recommended for risk stratification; however, there is no consensus as to which tool should be used for those with CAP. We sought to assess whether pneumonia-specific, generic sepsis or early warning scores were most accurate at predicting adverse outcomes. Methods: We performed a retrospective analysis of all cases of CAP admitted to a large, adult tertiary hospital in the UK between October 2014 and January 2016. All cases of CAP were eligible for inclusion and were reviewed by a senior respiratory physician to confirm the diagnosis. The association between the CURB65, Lac-CURB-65, quick Sequential (Sepsis-related) Organ Failure Assessment tool (qSOFA) score and National Early Warning Score (NEWS) at the time of admission and outcome measures including intensive care admission, length of hospital stay, in-hospital, 30-day, 90-day and 365-day all-cause mortality was assessed. Results: 1545 cases were included with 30-day mortality of 19%. Increasing score was significantly associated with increased risk of poor outcomes for all four tools. Overall accuracy assessed by receiver operating characteristic curve analysis was significantly greater for the CURB65 and Lac-CURB-65 scores than qSOFA. At admission, a CURB65 ≥2, Lac-CURB-65 ≥moderate, qSOFA ≥2 and NEWS ≥medium identified 85.0%, 96.4%, 40.3% and 79.0% of those who died within 30 days, respectively. A Lac-CURB-65 ≥moderate had the highest negative predictive value: 95.6%. Conclusion: All four scoring systems can stratify according to increasing risk in CAP; however, when a confident diagnosis of pneumonia can be made, these data support the use of pneumonia-specific tools rather than generic sepsis or early warning scores.
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