Evidence map›Paper›PMID 31258917›Full record

GuidelineBMJ open respiratory research2019

Guidelines on the management of acute respiratory distress syndrome.

Mark J D Griffiths, Danny Francis McAuley, Gavin D Perkins, Nicholas Barrett, Bronagh Blackwood, Andrew Boyle, Nigel Chee, Bronwen Connolly, Paul Dark, Simon Finney and 5 more

3 registry-linked trialsOpen access · goldAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in BMJ open respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 242 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 13 pooled it
55.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04380935 phase2 / phase3unknown statusnot on this mapstarted 2020, after this paper: background citation

Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome in Referral Hospitals in Indonesia

TypeinterventionalSponsorIndonesia UniversityRan2020 to 2020Enrolled60ConditionsCOVID, Acute Respiratory Distress SyndromeArmsConvalescent plasma, Standard of care
NCT04900129 phase1completednot on this mapstarted 2020, after this paper: background citation

Inhalation of Vapor With Medication (Diclofenac Sodium, Menthol, Methyl Salicylate and N-Acetyl Cysteine) Reduces Oxygen Need and Hospital Stay in COVID-19 Patients - A Case Control Study

TypeinterventionalSponsorSher-E-Bangla Medical CollegeRan2020 to 2020Enrolled43ConditionsCovid19ArmsMenthol 0.02%, Methyl salicylate 0.05%, N- Acetyl cysteine 1.2 gm%, and Diclofenac sodium 1gm%
NCT04969991 phase2terminatednot on this mapstarted 2021, after this paper: background citation

A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Varespladib in Patients Hospitalized With Severe COVID 19 Caused by SARS-CoV-2

TypeinterventionalSponsorOphirex, Inc.Ran2021 to 2022Enrolled18ConditionsCoronavirus Disease 2019, Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2ArmsVarespladib, Placebo
3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 13 syntheses or guidelines pooled it, 526 citations in OpenAlex.

  1. Pooled it
  2. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Guideline
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
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  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
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  19. Review
  20. Article

182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Mark J D GriffithsPeri-Operative Medicine, Barts Health NHS Trust, London, UK.ORCID 0000-0002-1615-1896
Danny Francis McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Belfast, UK.
Gavin D PerkinsWarwick Clinical Trials Unit, University of Warwick, Coventry, West Midlands, UK.
Nicholas BarrettCritical Care, Saint Thomas' Hospital, London, UK.
Bronagh BlackwoodWellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Belfast, UK.
Andrew BoyleWellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Belfast, UK.
Nigel CheeAcademic Department of Critical Care, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, UK.
Bronwen ConnollyRespiratory Medicine, King's College London, London, UK.
Paul DarkDivision of Infection, Immunity and Respiratory Medicine, NIHR Biomedical Research Centre, University of Manchester, Manchester, Greater Manchester, UK.
Simon FinneyPeri-Operative Medicine, Barts Health NHS Trust, London, UK.ORCID 0000-0001-8219-1952
Aemun SalamPeri-Operative Medicine, Barts Health NHS Trust, London, UK.
Jonathan SilversidesWellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Belfast, UK.
Nick TarmeyAcademic Department of Critical Care, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, UK.
Matt P WiseIntensive Care, Heath Hospital, Cardiff, UK.
Simon V BaudouinInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Queen's University Belfast · GBBarts Health NHS Trust · GBQueen Alexandra Hospital · GBKing's College London · GBNewcastle University · GBSt Thomas' Hospital · GBUniversity of Manchester · GBUniversity of Warwick · GB

Funding

Department of Health HTA/13/143/02Department of Health PDF-2015-08-015
6 · The paper itself

Abstract

The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development Group have used GRADE methodology to make the following recommendations for the management of adult patients with acute respiratory distress syndrome (ARDS). The British Thoracic Society supports the recommendations in this guideline. Where mechanical ventilation is required, the use of low tidal volumes (<6 ml/kg ideal body weight) and airway pressures (plateau pressure <30 cmH

Indexed as

Blood Gas AnalysisCombined Modality TherapyCritical CareExtracorporeal Membrane OxygenationGlucocorticoidsHumansPatient PositioningProne PositionRespiration, ArtificialRespiratory Distress SyndromeSocieties, MedicalTidal VolumeTreatment OutcomeUnited KingdomGlucocorticoidsARDS

Identifiers

PMID31258917
PMCPMC6561387
OpenAlexW2944849621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.