Evidence map›Paper›PMID 31258338›Full record

ArticleClinical Medicine Insights. Cardiology2019

Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Olutoyin Morenike Lawal, Michael Olabode Balogun, Anthony Olubunmi Akintomide, Oluwagbemiga Oluwole Ayoola, Tuoyo Omasan Mene-Afejuku, Oluwadare Ogunlade, Oluyomi Oluseun Okunola, Adekunle Oyeyemi Lawal, Adewale Akinsola

Abstract read
In one paragraph

Article in Clinical Medicine Insights. Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Olutoyin Morenike LawalDepartment of Medicine, State Specialist Hospital, Akure, Nigeria.ORCID https://orcid.org/0000-0002-3933-1953
Michael Olabode BalogunCardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Anthony Olubunmi AkintomideCardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Oluwagbemiga Oluwole AyoolaDepartment of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Tuoyo Omasan Mene-AfejukuDepartment of Medicine, Metropolitan Hospital Center, New York, NY, USA.
Oluwadare OgunladeCardiology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Oluyomi Oluseun OkunolaNephrology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Adekunle Oyeyemi LawalDepartment of Surgery, Federal Medical Center, Owo, Nigeria.
Adewale AkinsolaNephrology Unit, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.

methodsA case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.

resultsThe mean CIMT was higher in CKD population compared with controls (

conclusionsAs CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.

Indexed as

cardiovascular diseasecarotid intima-media thicknesschronic kidney disease

Identifiers

PMID31258338
PMCPMC6589967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.