ArticleHuman brain mapping2019
High-precision magnetoencephalography for reconstructing amygdalar and hippocampal oscillations during prediction of safety and threat.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Predictable and unpredictable deviance detection in the human hippocampus and amygdala.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Intrinsic Neural Timescales in the Temporal Lobe Support an Auditory Processing Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect.Frontiers in cellular neuroscience · 2023Article
- Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat.Scientific reports · 2021Article
- Co-registration Comparison of On-Scalp Magnetoencephalography and Magnetic Resonance Imaging.Frontiers in neuroscience · 2021Article
- Pragmatic spatial sampling for wearable MEG arrays.Scientific reports · 2020Article
- Representation of probabilistic outcomes during risky decision-making.Nature communications · 2020Article
- Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High-precision magnetoencephalography for reconstructing amygdalar and hippocampal oscillations during prediction of safety and threat.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
Abstract
Learning to associate neutral with aversive events in rodents is thought to depend on hippocampal and amygdala oscillations. In humans, oscillations underlying aversive learning are not well characterised, largely due to the technical difficulty of recording from these two structures. Here, we used high-precision magnetoencephalography (MEG) during human discriminant delay threat conditioning. We constructed generative anatomical models relating neural activity with recorded magnetic fields at the single-participant level, including the neocortex with or without the possibility of sources originating in the hippocampal and amygdalar structures. Models including neural activity in amygdala and hippocampus explained MEG data during threat conditioning better than exclusively neocortical models. We found that in both amygdala and hippocampus, theta oscillations during anticipation of an aversive event had lower power compared to safety, both during retrieval and extinction of aversive memories. At the same time, theta synchronisation between hippocampus and amygdala increased over repeated retrieval of aversive predictions, but not during safety. Our results suggest that high-precision MEG is sensitive to neural activity of the human amygdala and hippocampus during threat conditioning and shed light on the oscillation-mediated mechanisms underpinning retrieval and extinction of fear memories in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.