ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06210555 (Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls), which is not on this map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Multiparametric functional MRI for detection of early renal allograft dysfunction after kidney transplantation: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Trial
- Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study.Critical care (London, England) · 2022Trial
- Capability of arterial spin labeling combined with morphological characteristics to distinguish early- and mid-stage chronic kidney disease: a prospective study on 5 T MRI.Quantitative imaging in medicine and surgery · 2026Article
- First Experience with [Diagnostics (Basel, Switzerland) · 2026Article
- Integrating kidney imaging for risk prediction, therapeutic monitoring, and prognostication across the kidney disease spectrum: a review of emerging evidence.Clinical kidney journal · 2026Review
- Value of multiparametric MRI as a potential marker to differentiate membranous nephropathy from IgA nephropathy.BMC medical imaging · 2026Article
- Intra- and interobserver variability in renal multiparametric magnetic resonance imaging: T1 mapping, diffusion-weighted imaging, arterial spin labeling, blood oxygen level-dependent and renal artery flow measurements utilizing manual segmentation.Quantitative imaging in medicine and surgery · 2026Article
- Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Review
- Glomerulonephritis through the lens of ultrasound and radiology.World journal of nephrology · 2026Review
- Kidney MRI Texture Analysis-A Universal Assessment of Kidney State and Function?Journal of clinical medicine · 2026Article
- Associations between CT radiomics analyses and kidney biopsy in patients with kidney disease.BMC nephrology · 2026Article
- Cardiac-Gated Diffusion-Weighted Magnetic Resonance Imaging Assessment of Kidney Function in Patients With Kidney Cancer.Kidney international reports · 2026Article
- Assessing kidney fibrosis via multiparametric MRI in native kidney and allografts.Clinical kidney journal · 2026Article
- Quantitative assessment of renal function and perfusion changes in membranous nephropathy using multiparametric magnetic resonance imaging.Insights into imaging · 2026Article
- Influence of qNOX-guided remifentanil titration on intraoperative dosing and postoperative pain in total knee arthroplasty: a pilot randomized trial.Journal of anesthesia, analgesia and critical care · 2025Article
- Assessment of renal insufficiency in patients with renal artery stenosis by multiparametric magnetic resonance imaging.Renal failure · 2025Article
- Non-invasive assessment techniques for renal fibrosis: advances and perspectives.Renal failure · 2025Review
- Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.Journal of nephrology · 2025Article
- The association of plasma testosterone level and progression of diabetic nephropathy in male.BMC endocrine disorders · 2025Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMulti-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated in chronic kidney disease (CKD).
methodsWe performed multi-parametric renal MRI in persons with CKD (n = 22, 61 ± 24 years) who had a renal biopsy and measured glomerular filtration rate (mGFR), and matched healthy volunteers (HV) (n = 22, 61 ± 25 years). Longitudinal relaxation time (T1), diffusion-weighted imaging, renal blood flow (phase contrast MRI), cortical perfusion (arterial spin labelling) and blood-oxygen-level-dependent relaxation rate (R2*) were evaluated.
resultsMRI evidenced excellent reproducibility in CKD (coefficient of variation <10%). Significant differences between CKD and HVs included cortical and corticomedullary difference (CMD) in T1, cortical and medullary apparent diffusion coefficient (ADC), renal artery blood flow and cortical perfusion. MRI measures correlated with kidney function in a combined CKD and HV analysis: estimated GFR correlated with cortical T1 (r = -0.68), T1 CMD (r = -0.62), cortical (r = 0.54) and medullary ADC (r = 0.49), renal artery flow (r = 0.78) and cortical perfusion (r = 0.81); log urine protein to creatinine ratio (UPCR) correlated with cortical T1 (r = 0.61), T1 CMD (r = 0.61), cortical (r = -0.45) and medullary ADC (r = -0.49), renal artery flow (r = -0.72) and cortical perfusion (r = -0.58). MRI measures (cortical T1 and ADC, T1 and ADC CMD, cortical perfusion) differed between low/high interstitial fibrosis groups at 30-40% fibrosis threshold.
conclusionComprehensive multi-parametric MRI is reproducible and correlates well with available measures of renal function and pathology. Larger longitudinal studies are warranted to evaluate its potential to stratify prognosis and response to therapy in CKD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.