Evidence map›Paper›PMID 31257143›Full record

ArticleCurrent biology : CB2019

The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.

Ioanna Leontiou, Nitobe London, Karen M May, Yingrui Ma, Lucile Grzesiak, Bethan Medina-Pritchard, Priya Amin, A Arockia Jeyaprakash, Sue Biggins, Kevin G Hardwick

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  7. A coadapted KNL1 and spindle assembly checkpoint axis orchestrates precise mitosis in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  14. BiallelicScience advances · 2022
    Article
  15. Article
  16. Article
  17. Spindle assembly checkpoint activation and silencing at kinetochores.Seminars in cell & developmental biology · 2021
    Review
  18. [BUB1 gene is highly expressed in gastric cancer:analysis based on Oncomine database and bioinformatics].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ioanna LeontiouInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Nitobe LondonHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Karen M MayInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Yingrui MaInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Lucile GrzesiakInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Bethan Medina-PritchardInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Priya AminInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
A Arockia JeyaprakashInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Sue BigginsHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Kevin G HardwickInstitute of Cell Biology, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK. Electronic address: kevin.hardwick@ed.ac.uk.
University of Edinburgh · GBFred Hutch Cancer Center · USHoward Hughes Medical Institute · US

Funding

Regulation of Chromosome SegregationR01GM064386 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BIGGINS, SUSAN · 2002 to 2022
$7.2M
Howard Hughes Medical InstituteMedical Research Council MR/K501293/1NIGMS NIH HHS R01 GM064386Wellcome Trust 092076Wellcome Trust 108105Wellcome Trust 202811/Z/16/ZWellcome Trust 203149
6 · The paper itself

Abstract

The spindle checkpoint monitors kinetochore-microtubule interactions and generates a "wait anaphase" delay when any defects are apparent [1-3]. This provides time for cells to correct chromosome attachment errors and ensure high-fidelity chromosome segregation. Checkpoint signals are generated at unattached chromosomes during mitosis. To activate the checkpoint, Mps1

Indexed as

Cell Cycle ProteinsM Phase Cell Cycle CheckpointsNuclear ProteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSchizosaccharomycesSchizosaccharomyces pombe ProteinsTetratricopeptide RepeatBub1 protein, S cerevisiaeBub1 protein, S pombeCell Cycle ProteinsMAD3 protein, S cerevisiaemad3 protein, S pombeNuclear ProteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe ProteinsBub1Mad3mitosisMps1spindle checkpointTPR domain

Identifiers

PMID31257143
PMCPMC6657678
OpenAlexW2954465692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.