ArticleOphthalmology. Retina2019
Signal Strength Reduction Effects in OCT Angiography.
Article in Ophthalmology. Retina, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Evaluation of retina and microvascular changes in the patient with Parkinson's disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial.Translational vision science & technology · 2024Trial
- Image Quality as an Important Confounder in Quantitative OCT Angiography: A Review with Quantitative Synthesis.Medical sciences (Basel, Switzerland) · 2026Review
- Effect of Optical Coherence Tomography Angiography Image Artifacts on Quantitation of Vessel Density and Perfusion.Ophthalmic surgery, lasers & imaging retina · 2026Article
- A multimodal machine-learning diagnostic model for Alzheimer's disease: integrating OCTA-derived retinal microvascular features and clinical variables.Frontiers in aging neuroscience · 2026Article
- Analysis of the Retinal Microcirculation in Chinese Patients With Vogt-Koyanagi-Harada Disease by Optical Coherence Tomography Angiography.Translational vision science & technology · 2025Article
- Retinal optical coherence tomography angiography imaging in population studies for study of microvascular dysfunction in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Artificial Intelligence Versus Rules-Based Approach for Segmenting NonPerfusion Area in a DRCR Retina Network Optical Coherence Tomography Angiography Dataset.Investigative ophthalmology & visual science · 2025Article
- Retinal microvascular density and inner thickness in Alzheimer's disease and mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Retinal microstructure and microvasculature in association with brain amyloid burden.Brain communications · 2025Article
- Quantitative Evaluation of Type 1 and Type 2 Choroidal Neovascularization Components Under Treatment With Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2024Article
- Optimization of handheld spectrally encoded coherence tomography and reflectometry for point-of-care ophthalmic diagnostic imaging.Journal of biomedical optics · 2024Article
- Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis.Journal of clinical medicine · 2024Review
- Astigmatism Influences Quantitative and Qualitative Analysis in Optical Coherence Tomography Angiography Imaging.Translational vision science & technology · 2024Article
- Factors affecting optical coherence tomography angiography signal strength index in patients receiving intravitreal injection treatment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison.Investigative ophthalmology & visual science · 2023Article
- The Effect of Circle of Willis Morphology on Retinal Blood Flow in Patients with Carotid Stenosis Measured by Optical Coherence Tomography Angiography.Journal of clinical medicine · 2023Article
- Convolutional Neural Network-Based Automated Quality Assessment of OCT and OCT Angiography Image Maps in Individuals With Neurodegenerative Disease.Translational vision science & technology · 2023Article
- The Impact of Cataracts on the Measurement of Macular Choriocapillaris Flow Deficits Using Swept-Source OCT Angiography.Translational vision science & technology · 2023Article
- Ocular and systemic determinants of perifoveal and macular vessel parameters in healthy African Americans.The British journal of ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo elucidate the relationship between vessel density (VD) measurements and signal strength in OCT angiography (OCTA).
designCross-sectional study.
participantsHealthy volunteers.
methodsOCT angiography images obtained from healthy volunteers were analyzed to demonstrate the relationship between signal strength index (SSI) and VD. Experiments were performed to determine the effects of signal strength reduction on VD measurements on the Optovue/AngioVue (Optovue, Inc, Fremont, CA) and Cirrus/AngioPlex OCTA (Carl Zeiss Meditec, Inc, Dublin, CA) systems. Signal strength reduction was generated by either neutral density filters (NDFs) or defocus.
main outcome measuresRegression analysis of signal strength effects on VD.
resultsVessel density decreased linearly with signal strength with high statistical significance on both OCTA systems tested and for all analyzed sources of variation in signal strength. The slope of VD versus SSI was greatest when signal strength was adjusted by NDFs, followed by defocus, interscan difference, interindividual variation, and left-right eye difference. Multivariate analysis revealed that both SSI and age had a significant effect on the interindividual variation in VD.
conclusionsVessel density measurements using OCTA were affected significantly by OCT signal strengths on 2 OCTA platforms. Investigators should exercise caution when interpreting VD data from OCTA scans. Quantification algorithms for OCTA should ideally remove the signal strength bias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.