ArticleCell2019
Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner.
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Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 877 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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877citing papers in PubMed, 2 pooled it
51.0field-weighted citation impact, top 1% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
877 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,272 citations in OpenAlex.
- Macrophage-associated kinase signaling in atherosclerosis - a systematic review.Cell communication and signaling : CCS · 2026Pooled it
- Metabolic regulation and immunosuppressive functions of lipid-associated macrophages in pancreatic ductal adenocarcinoma.Frontiers in immunology · 2026Pooled it
- PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Trial
- Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction-associated steatohepatitis.Bioactive materials · 2027Article
- Short-chain fatty acid-producing commensals: Key modulators of AD neuroinflammation via the microbiota-gut-brain axis.Current research in microbial sciences · 2026Review
- Epitope-diverse autoantibodies induce neutrophil-epithelial niches driving kidney injury in ANCA-associated glomerulonephritis.The Journal of experimental medicine · 2026Article
- Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research.Signal transduction and targeted therapy · 2026Review
- Article
- Single-cell RNA sequencing reveals the interaction of TREM2Immunologic research · 2026Article
- Berberine Prevents and Reverses Gastric Spasmolytic Polypeptide-Expressing Metaplasia by Modulating M2 Macrophage Polarization.International journal of molecular sciences · 2026Article
- Chronic Radiation-Induced Wounds: Pathogenesis, Current Therapeutic Strategies, and Emerging Regenerative Approaches.International journal of molecular sciences · 2026Review
- Review
- Explainable Artificial Intelligence and Gene-Network Analysis Prioritise a TREM2/LGALS3/GPNMB Scar-Associated Macrophage Programme in Human Liver Cirrhosis.International journal of molecular sciences · 2026Article
- Exploratory single-nucleus multiomics analysis of myeloid cell states associated with neoadjuvant chemotherapy response in pancreatic ductal adenocarcinoma.Clinical and translational medicine · 2026Article
- Pathophysiological roles of monocytes and macrophages in cancer.Nature reviews. Immunology · 2026Review
- Tissue-Resident Macrophage in Inflammation and Cancer.MedComm · 2026Review
- CFTR regulates lipid metabolism by relieving adipose inflammation in obesity.International journal of obesity (2005) · 2026Article
- Article
- Understanding adipocyte heterogeneity across species, depot, and disease.Biochemical Society transactions · 2026Review
817 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 9 institutions in 4 countries.
Diego Adhemar JaitinDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Lorenz AdlungDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Christoph A ThaissDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Assaf WeinerDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Baoguo LiDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Hélène DescampsDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Patrick LundgrenDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Camille BleriotSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Biopolis, Singapore 138648, Singapore.
Zhaoyuan LiuShanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
Aleksandra DeczkowskaDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Hadas Keren-ShaulDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Eyal DavidDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Niv ZmoraDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Shai Meron EldarDivision of Surgery, Tel-Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Nir LubezkyDivision of Surgery, Tel-Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Oren ShiboletResearch Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
David A HillInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Mitchell A LazarInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Biopolis, Singapore 138648, Singapore; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
Hagit ShapiroDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Eran ElinavDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: eran.elinav@weizmann.ac.il.
Ido AmitDepartment of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: ido.amit@weizmann.ac.il.
Weizmann Institute of Science · ILUniversity of Pennsylvania · USTel Aviv University · ILAgency for Science, Technology and Research · SGChildren's Hospital of Philadelphia · USShanghai Jiao Tong University · CNSingapore Immunology Network · SGTel Aviv Sourasky Medical Center · ILWashington University in St. Louis · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MNuclear Receptors in Metabolic TissuesR01DK049780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LAZAR, MITCHELL A. · 1995 to 2025
$10.8MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MThe role of unique adipose tissue macrophage populations in obesityK08DK116668 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HILL, DAVID ANDREW · 2018 to 2022
$770kAdvancing Child Health: Preparing the Next Generation of Pediatric Researchers.R25HD082842 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI KRANTZ, IAN D. · 2015 to 2019
$540kHoward Hughes Medical InstituteNIAMS NIH HHS P30 AR069589NICHD NIH HHS R25 HD082842NIDDK NIH HHS K08 DK116668NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK050306NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK049780
Abstract
Immune cells residing in white adipose tissue have been highlighted as important factors contributing to the pathogenesis of metabolic diseases, but the molecular regulators that drive adipose tissue immune cell remodeling during obesity remain largely unknown. Using index and transcriptional single-cell sorting, we comprehensively map all adipose tissue immune populations in both mice and humans during obesity. We describe a novel and conserved Trem2
Indexed as
Adipose Tissue, WhiteAnimalsDiet, High-FatGlucose IntoleranceHumansIntra-Abdominal FatLipid MetabolismLipidsMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMonocytesObesityReceptors, ImmunologicLipidsMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseAlzheimer diseasefatty liver diseasesimmunologymacrophagesmetabolic diseasesmetabolismobesitysingle-cell genomicssystems biologyTrem2 pathway
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.