ArticleCell2019
Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
197 citing papers in PubMed, 356 citations in OpenAlex.
- Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks.Nature neuroscience · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.Cell reports methods · 2026Article
- Protocol for longitudinal two-photon calcium imaging and holographic optogenetic manipulation to investigate memory in mice.STAR protocols · 2026Article
- Neuronal ensembles in cortical function and disease.Physiological reviews · 2026Review
- The Importance of Synchrony in the Neural Control of Movement.bioRxiv : the preprint server for biology · 2026Article
- Single-Cell Perturbations Reveal Selective Modulation of Causal Connectivity During Decision-Making.bioRxiv : the preprint server for biology · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.bioRxiv : the preprint server for biology · 2026Article
- The axon initial segment-associated microglia regulate neuronal activity and visual perception.Cell research · 2026Article
- Functional reorganization of motor cortex connectivity during learning.bioRxiv : the preprint server for biology · 2026Article
- Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026Article
- 2P-FENDO-II: A fiber bundle microscope for all-optical, large field-of-view brain studies in freely moving mice.Cell reports methods · 2026Article
- Active pixel power control for crosstalk-free all-optical neural interrogation.Nature communications · 2026Article
- Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.Nature communications · 2026Article
- Convergent information flows explain recurring firing patterns in cerebral cortex.Nature neuroscience · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Critical scaling of novelty in the cortex.Nature communications · 2026Article
- Patterned wireless transcranial optogenetics generates artificial perception.Nature neuroscience · 2026Article
- A proposal for realizing cognitive functions using traveling waves, phase-locked and synchronized patterns, holography, neural mixing, and single sideband communications.Frontiers in computational neuroscience · 2026Article
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
137 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task. Disruption of behaviorally relevant ensembles by activation of non-selective neurons decreased performance, whereas activation of only two pattern completion neurons from behaviorally relevant ensembles improved performance, by reliably recalling the whole ensemble. Also, inappropriate behavioral choices were evoked by the mistaken activation of behaviorally relevant ensembles. Finally, in absence of visual stimuli, optogenetic activation of two pattern completion neurons could trigger behaviorally relevant ensembles and correct behavioral responses. Our results demonstrate a causal role of neuronal ensembles in a visually guided behavior and suggest that ensembles implement internal representations of perceptual states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.