Evidence map›Paper›PMID 31257028›Full record

ArticleCell2019

Regulation of Energy Expenditure by Brainstem GABA Neurons.

Marc Schneeberger, Luca Parolari, Tania Das Banerjee, Varun Bhave, Putianqi Wang, Bindiben Patel, Thomas Topilko, Zhuhao Wu, Chan Hee J Choi, Xiaofei Yu and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 104 citations in OpenAlex.

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  15. An arginine-rich nuclear localization signal (ArgiNLS) strategy for streamlined image segmentation of single cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Marc SchneebergerLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: mschneeber@rockefeller.edu.
Luca ParolariLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Tania Das BanerjeePrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Varun BhavePrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Putianqi WangLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Bindiben PatelPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Thomas TopilkoICM, Brain and Spine Institute, Hopital de la Pitie-Salpetriere, Sorbonne Universite, Inserm, CNRS, Paris 75013, France.
Zhuhao WuLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Chan Hee J ChoiLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Xiaofei YuLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Kyle PellegrinoLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Esteban A EngelPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA.
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Nicolas RenierICM, Brain and Spine Institute, Hopital de la Pitie-Salpetriere, Sorbonne Universite, Inserm, CNRS, Paris 75013, France.
Jeffrey M FriedmanLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: friedj@rockefeller.edu.
Alexander R NectowPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: arn2136@columbia.edu.
Howard Hughes Medical Institute · USPrinceton University · USRockefeller University · USPitié-Salpêtrière Hospital · FRSorbonne Université · FR

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
Understanding how the thermogenic response is orchestrated in the central nervous systemK99DK120869 · NIDDK · ROCKEFELLER UNIVERSITY · PI SCHNEEBERGER, MARC · 2020 to 2021
$233k
Howard Hughes Medical InstituteNIDDK NIH HHS K99 DK120869NIH HHS P40 OD010996
6 · The paper itself

Abstract

Homeostatic control of core body temperature is essential for survival. Temperature is sensed by specific neurons, in turn eliciting both behavioral (i.e., locomotion) and physiologic (i.e., thermogenesis, vasodilatation) responses. Here, we report that a population of GABAergic (Vgat-expressing) neurons in the dorsolateral portion of the dorsal raphe nucleus (DRN), hereafter DRN

Indexed as

Energy MetabolismAdipose Tissue, BrownAnimalsBrain MappingClozapineDorsal Raphe NucleusGABAergic NeuronsGene ExpressionGenetic VectorsMiceMice, Inbred C57BLMice, TransgenicOptogeneticsTemperatureThermogenesisClozapineclozapine N-oxide

Identifiers

PMID31257028
PMCPMC7481042
OpenAlexW2954262723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.