Evidence map›Paper›PMID 31257007›Full record

ArticleInternational journal of orthopaedic and trauma nursing2019

Genotype, resilience and function and physical activity post hip fracture.

Barbara Resnick, N Jennifer Klinedinst, Laura Yerges-Armstrong, Jay Magaziner, Denise Orwig, Marc C Hochberg, Ann L Gruber-Baldini, Susan G Dorsey

Abstract read
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In one paragraph

Article in International journal of orthopaedic and trauma nursing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara ResnickUniversity of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD 21201, USA. Electronic address: Resnick@son.umaryland.edu.
N Jennifer KlinedinstUniversity of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD 21201, USA.
Laura Yerges-ArmstrongProgram in Personalized Medicine, Division of Endocrinology, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore St., Baltimore, MD 21201, USA.
Jay MagazinerUniversity of Maryland, School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD 21201, USA.
Denise OrwigUniversity of Maryland, School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD 21201, USA.
Marc C HochbergUniversity of Maryland, School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA.
Ann L Gruber-BaldiniUniversity of Maryland, School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD 21201, USA.
Susan G DorseyUniversity of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD 21201, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
Understanding Variations in Hip Fracture Outcomes across the Continuum of CareK08AG043548 · NIA · UNIVERSITY OF PENNSYLVANIA · PI NEUMAN, MARK DAVID · 2012 to 2016
$642k
NIA NIH HHS K08 AG043548NIA NIH HHS P30 AG028747NIA NIH HHS R37 AG009901
6 · The paper itself

Abstract

backgroundIndividuals who are resilient are more likely to engage in functional tasks and exercise post hip fracture. There may be a genetic predisposition to being resilient.

objectivesThis study tested the direct and indirect association of 10 candidate genes, age, cognition, gender, comorbidities, pain and social activity on resilience, function and exercise post hip fracture.

methodThis was a descriptive study including 172 community dwelling older adults. Measures included: age, gender, cognition (Modified Mini Mental Status Exam), comorbidities, social activities (self-report), DNA (GRM1, NTRK1, NTRK2, GNB3, NPY, SLC6A15. SLC6A4, BDNF, CR1TR1, FKBP5), pain (areas of pain and Numeric Rating Scale), function (Physical and Instrumental Activities of Daily Living; Lower Extremity Gains Score; Short Physical Performance Battery; Grip Strength) and exercise (Yale Physical Activity Scale).

resultsThe majority of participants were Caucasian (93%), 50% were women and the average age was 81.09 (SD = 7.42). There were significant associations between resilience and single nucleotide polymorphisms from GRM1, NTRK1, NTRK2, GNB3, NPY and SLC6A15. Resilience, age, cognition, social activity, pain and genetic variability were directly and/or indirectly associated with exercise and/or function. DISCUSSION: This study highlights the importance of resilience for engagement in exercise and function after hip fracture and provides preliminary evidence for a genetic role for resilience.

Indexed as

ExerciseGenotypeAgedAged, 80 and overAge FactorsFemaleHip FracturesHumansMalePainRange of Motion, ArticularRecovery of FunctionexercisefunctionGeneticsresilience

Identifiers

PMID31257007
PMCPMC7069656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.