Evidence map›Paper›PMID 31256738›Full record

ArticleLeukemia & lymphoma2019

High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing.

Zaal Meher-Homji, Constantine S Tam, Jim Siderov, John Francis Seymour, Natasha E Holmes, Kyra Y L Chua, Elizabeth J Phillips, Monica A Slavin, Jason A Trubiano

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia & lymphoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Skin changes in hairy cell leukemia.Annals of hematology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zaal Meher-HomjiDepartment of Infectious Diseases, Austin Health, Heidelberg, Australia.ORCID 0000-0003-4636-3678
Constantine S TamDepartment of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia.ORCID 0000-0002-9759-5017
Jim SiderovDepartment of Pharmacy, Austin Health, Heidelberg, Australia.
John Francis SeymourDepartment of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia.ORCID 0000-0003-2188-6835
Natasha E HolmesDepartment of Infectious Diseases, Austin Health, Heidelberg, Australia.ORCID 0000-0001-8501-4054
Kyra Y L ChuaDepartment of Infectious Diseases, Austin Health, Heidelberg, Australia.
Elizabeth J PhillipsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Monica A SlavinDepartment of Medicine, University of Melbourne, Melbourne, Australia.ORCID 0000-0002-8443-314X
Jason A TrubianoDepartment of Infectious Diseases, Austin Health, Heidelberg, Australia.ORCID 0000-0002-5111-6367

Funding

Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C. · 2015 to 2019
$13.0M
Single Cell definition of pathogenic T cells in Drug-induced Stevens-Johnson-Syndrome/Toxic epidermal necrolysisR21AI139021 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2018 to 2019
$435k
NIAID NIH HHS R21 AI139021NIGMS NIH HHS P50 GM115305
6 · The paper itself

Abstract

The relationship between hematological malignancy and chemotherapy on the prevalence of antibiotic allergy label (AAL) is ill-defined. We performed a multicenter retrospective case-control study comparing AAL rates among cladribine-treated hairy cell leukemia (C-HCL) cases, non-HCL cladribine-treated controls (control-1), and fludarabine-treated controls (control-2). The prevalence of AALs in C-HCL patients was 60%, compared with control-1 (14%,

Indexed as

AdultAgedAnti-Bacterial AgentsAntineoplastic Combined Chemotherapy ProtocolsAustraliaCase-Control StudiesCladribineDrug HypersensitivityFemaleFollow-Up StudiesHumansLeukemia, Hairy CellMaleMiddle AgedPrevalencePrognosisAnti-Bacterial AgentsCladribinefludarabineVidarabineallergyantibioticscladribineHairy cell leukemiamaculopapular exanthem

Identifiers

PMID31256738
PMCPMC6928424

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.