ArticleHypertension (Dallas, Tex. : 1979)2019
Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART.
Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Assessing cardiovascular benefits of intensive blood pressure lowering in high-risk undiagnosed HFpEF patients.ESC heart failure · 2025Trial
- Effects of Blood Pressure Control on Arterial Stiffness Mechanisms in SPRINT: A Randomized Controlled Trial.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Effect of Lower Blood Pressure Goals on Left Ventricular Structure and Function in Patients With Subclinical Hypertensive Heart Disease.American journal of hypertension · 2020Trial
- Hypertensive Heart Failure with Preserved Ejection Fraction: Guidelines vs. Randomized Controlled Trials Evidence Gaps.Medicina (Kaunas, Lithuania) · 2026Review
- Blood Flow Restriction Training Improves Cardiac Structure and Diastolic Function in Runners with Exercise-Induced Hypertension.Journal of clinical medicine · 2025Article
- Three-Year Echocardiographic Follow-Up in Outpatients with Systemic Arterial Hypertension: An Observational Cohort Study.Journal of clinical medicine · 2025Article
- Global prevalence and disability-adjusted life years of hypertensive heart disease: A trend analysis from the Global Burden of Disease Study 2019.Journal of global health · 2024Article
- Electrocardiographic tracking of left ventricular hypertrophy in hypertension: incidence and prognostic outcomes from the SPRINT trial.Clinical hypertension · 2024Article
- Left ventricle remodeling by CMR in treated patients with primary aldosteronism and primary systemic arterial hypertension.PloS one · 2024Article
- Impact of Anemia on Cardiovascular Events and All-Cause Death Among Participants Who Received Intense Blood Pressure Treatment: A Secondary Analysis of SPRINT.Reviews in cardiovascular medicine · 2024Article
- Review
- Exploring the Relationship Between Intensive Blood Pressure Lowering, Left Ventricular Hypertrophy, and Cardiovascular Outcomes.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Subclinical HMOD in Hypertension: Left Ventricular Diastolic Dysfunction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Review
- Global, regional, and national burden of hypertensive heart disease during 1990-2019: an analysis of the global burden of disease study 2019.BMC public health · 2022Article
- Cardiac sympathetic dysfunction in left ventricular hypertrophy caused by arterial hypertension and degenerative aortic stenosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Prognostic implication of left ventricular hypertrophy regression after antihypertensive therapy in patients with hypertension.Frontiers in cardiovascular medicine · 2022Article
- Association of Office and Ambulatory Blood Pressure with Left Ventricular Structure and Function in Hypertensive Patients.International journal of general medicine · 2022Article
- Risk-Based Intensive Blood Pressure Lowering and Prevention of Heart Failure: A SPRINT Post Hoc Analysis.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Hypertensive Heart Failure in Asia.Pulse (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 1 country.
Funding
Abstract
In observational studies, left ventricular mass (LVM) and structure are strong predictors of mortality and cardiovascular events. However, the effect of hypertension treatment on LVM reduction and its relation to subsequent outcomes is unclear, particularly at lower blood pressure (BP) targets. In an ancillary study of SPRINT (Systolic Blood Pressure Intervention Trial), where participants were randomly assigned to intensive BP control (target systolic BP target <120 mm Hg) versus standard BP control (<140 mm Hg), cardiac magnetic resonance imaging was performed at baseline and 18-month follow-up to measure: LVM, volumes, ejection fraction, and native T1 mapping for myocardial fibrosis. At baseline, 337 participants were examined (age: 64±9 years, 45% women); 300 completed the 18-month exam (153 intensive control and 147 standard control). In the intensive versus standard BP control group at 18 months, there was no difference in change in LVM (mean±SE =-2.7±0.5 g versus -2.3±0.7 g;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.