Observational studyJournal of clinical hypertension (Greenwich, Conn.)2019
Acute-phase blood pressure trajectories and clinical outcomes in ischemic stroke.
Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systolic blood pressure trajectories after acute ischemic strokes and clinical outcomes: A systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Nomogram to predict 3 month prognosis of acute ischemic stroke among young adults.Frontiers in neurology · 2024Article
- Acute-phase heart rate trajectories and functional outcomes in acute ischemic stroke.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- One-Year Blood Pressure Trajectory After Acute Ischemic Stroke.Journal of the American Heart Association · 2022Article
- Association between the Systolic Blood Pressure Trajectory and Risk of Stroke in a Health-Management Population in Jiaozuo, China.Journal of healthcare engineering · 2022Article
- Blood pressure trajectories after stroke: Do they matter?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Acute in-hospital blood pressure variability predicts early neurological deterioration in acute minor stroke or transient ischemic attack with steno-occlusive arterial disease.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Acute-phase blood pressure trajectories and clinical outcomes in ischemic stroke.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
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Authors and funding
11 authors.
Funding
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Abstract
High blood pressure (BP) is frequent in acute ischemic stroke (IS). However, the impact of BP change patterns during acute phase on clinical outcomes is not conclusive. This study aims to investigate the association between the acute-phase BP trajectories and clinical outcomes in IS patients with high admission BP. The cohort consisted of 316 IS patients with admission systolic BP (SBP) ≥160 mm Hg. SBP trajectories during the first 7 days after onset were characterized using a random effects model. The patients were classified into three groups based on the SBP trajectory curve parameters: sustained high SBP (T1), moderate decrease (T2), and rapid decrease in SBP (T3). Poor outcomes were defined as modified Rankin scale score ≥3 in 3 months after onset. The relationship between SBP trajectory groups and the outcome was examined in multivariable logistic regression models. The decreasing trend was greater in the favorable than in the poor outcome group (P = 0.028 for difference in linear slopes). The incidence of poor outcomes was 25.9%, 13.5%, and 9.8% in T1 (n = 54), T2 (n = 170), and T3 (n = 92) groups, respectively. Compared with T1 group, the decrease in SBP in T2 and T3 groups was significantly associated with lower risk of the poor outcome (odds ratio = 0.25, 95% confidence interval = 0.10-0.67, P = 0.006). These findings suggest that a decrease in BP in the acute phase is predictive of favorable outcomes in IS patients. BP trajectories have a greater power to detect the association than individual BP values at one time-point.
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