ArticleEnvironmental science and pollution research international2019
Cadmium overload modulates piroxicam-regulated oxidative damage and apoptotic pathways.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Empagliflozin Inhibits Cadmium-Induced Hepatic Cell Apoptosis Through Endoplasmic Reticulum Stress and Autophagy Pathways.Biological trace element research · 2025Article
- Investigation of Cannabidiol's Protective Effects on Cadmium-Induced Toxicity in Mice.Basic & clinical pharmacology & toxicology · 2025Article
- Anacyclus pyrethrum enhances fertility in cadmium-intoxicated male rats by improving sperm functions.BMC complementary medicine and therapies · 2024Article
- Degradation of piroxicam and celecoxib from aqueous solution by high-energy electron beam as a Sustainable method.Heliyon · 2024Article
- Iron Administration Partially Ameliorates Cadmium-Induced Oxidative Damage in the Liver and Kidney of Rats.Journal of toxicology · 2024Article
- Ameliorative Effects of Oyster Protein Hydrolysates on Cadmium-Induced Hepatic Injury in Mice.Marine drugs · 2022Article
- Tigecycline and Gentamicin-Combined Treatment Enhances Renal Damage: Oxidative Stress, Inflammatory Reaction, and Apoptosis Interplay.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Transcriptomics and transmission ultrastructural examination reveals the nephrotoxicity of cadmium in laying hens.Environmental science and pollution research international · 2022Article
- Article
- The Combination ofFrontiers in pharmacology · 2022Article
- Bioactive phytochemicals from Salvia officinalis attenuate cadmium-induced oxidative damage and genotoxicity in rats.Environmental science and pollution research international · 2021Article
- Regulatory effects of quercetin on testicular histopathology induced by cyanide in Wistar rats.Heliyon · 2021Article
- Oxidative stress in liver of turtle Mauremys reevesii caused by cadmium.Environmental science and pollution research international · 2021Article
- Potentiation of the apoptotic signaling pathway in both the striatum and hippocampus and neurobehavioral impairment in rats exposed chronically to a low-dose of cadmium.Environmental science and pollution research international · 2021Article
- Correlation between blood levels of cadmium and lead and the expression of microRNA-21 in Egyptian bladder cancer patients.Heliyon · 2020Article
- Synthesized chrysin-loaded nanoliposomes improves cadmium-induced toxicity in mice.Environmental science and pollution research international · 2020Article
- Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Rosa persica hydroalcoholic extract improves cadmium-hepatotoxicity by modulating oxidative damage and tumor necrosis factor-alpha status.Environmental science and pollution research international · 2020Article
- Effects of dietary cadmium supplementation on production performance, cadmium residue in eggs, and hepatic damage in laying hens.Environmental science and pollution research international · 2020Article
- Protective effect assessment of Moringa oleifera against cadmium-induced toxicity in HCT116 and HEK293 cell lines.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadmium (Cd) is a common environmental pollutant that threatens humans' and animals' health. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used drugs due to their wide therapeutic action; however, they have significant side effects. Since, under many circumstances, humans and animals may be co-exposed to Cd and NSAIDs, the current investigation was assigned to explore the intertwining relationship between Cd and NSAIDs. Four groups of male Wister rats were used: control group: rats received saline; Cd group: rats received cadmium (Cd, 2 mg/kg) orally; Px group: rats received a NSAID (piroxicam, Px, 7 mg/kg, i.p.); and Cd+Px group: rats received both Cd+Px. All treatments were given once a day for 28 consecutive days. Then, blood samples, stomach, liver, and kidney tissues were collected. The results indicated that Px provoked gastric ulcer indicated by high ulcer index, while Cd had no effect on the gastric mucosa. In addition, treatment with Cd or Px alone significantly induced liver and kidney injuries indicated by serum elevations of AST, ALT, ALP, ALB, total protein, creatinine, and urea along with histopathological alterations. Significant increases in malondialdehyde and reduction in GSH and CAT contents were reported along with up-regulated expression of Bax and Bcl-2 after Cd or Px exposure. However, when Cd and Px were given in a combination, Cd obviously potentiated the Px-inflicted cellular injury and death in the liver and kidney but not in the stomach when compared to their individual exposure. This study concluded that oxidative stress mechanisms were supposed to be the main modulator in promoting Cd and Px toxicities when given in combination.
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