Evidence map›Paper›PMID 31256356›Full record

Trial reportObesity surgery2019

Changes in Gut Microbiome after Bariatric Surgery Versus Medical Weight Loss in a Pilot Randomized Trial.

Clare J Lee, Liliana Florea, Cynthia L Sears, Nisa Maruthur, James J Potter, Michael Schweitzer, Thomas Magnuson, Jeanne M Clark

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01667783 (Improving Diabetes Through Lifestyle and Surgery Study), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01667783 phase2 / phase3completednot on this map

Improving Diabetes Through Lifestyle and Surgery Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2012 to 2015Enrolled15ConditionsObesity, Type 2 DiabetesArmsGastric Banding, Medical Weight Loss, Gastric Bypass
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Clare J LeeDivisions of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, 1830 E. Monument St, Baltimore, MD, 21287, USA. clee158@jhmi.edu.ORCID 0000-0002-0824-0207
Liliana FloreaDivision of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Cynthia L SearsBloomberg-Kimmel Institute for Cancer Immunotherapy, The Johns Hopkins University, Baltimore, MD, USA.
Nisa MaruthurDivision of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA.
James J PotterDivision of Gastroenterology and Hepatology, The Johns Hopkins University, Baltimore, MD, USA.
Michael SchweitzerDepartment of Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Thomas MagnusonDepartment of Surgery, The Johns Hopkins University, Baltimore, MD, USA.
Jeanne M ClarkDivision of General Internal Medicine, The Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USBloomberg (United States) · US

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2011 to 2020
$12.0M
Mechanisms and Effectiveness of Weight Loss Methods on Diabetes and Sleep ApneaR01DK089557 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L, CLARK, JEANNE M · 2010 to 2012
$1.5M
Exploring Mechanisms of Changes in Glucose Homeostasis After Bariatric Surgery: Comparing Vertical Sleeve Gastrectomy and Roux-en-Y Gastric BypassK23DK107921 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LEE, CLARE JUNG EUN · 2016 to 2018
$582k
NIDDK NIH HHS 1R01DK089557NIDDK NIH HHS DK089502-01NIDDK NIH HHS K23DK107921NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK089557NIH HHS 5KL2TR001077-02
6 · The paper itself

Abstract

backgroundGut microbiota likely impact obesity and metabolic diseases. We evaluated the changes in gut microbiota after surgical versus medical weight loss in adults with diabetes and obesity.

methodsWe performed 16S rRNA amplicon sequencing to identify the gut microbial composition at baseline and at 10% weight loss in adults with diabetes who were randomized to medical weight loss (MWL, n = 4), adjustable gastric banding (AGB, n = 4), or Roux-en-Y gastric bypass (RYGB, n = 4).

resultsAll participants were female, 75% reported black race with mean age of 51 years. At similar weight loss amount and glycemic improvement, the RYGB group had the most number of bacterial species (10 increased, 1 decreased) that significantly changed (p < 0.05) in relative abundance. Alpha-diversity at follow-up was significantly lower in AGB group compared to MWL and RYGB (observed species for AGB vs. MWL, p = 0.0093; AGB vs. RYGB, p = 0.0093). The relative abundance of Faecalibacterium prausnitzii increased in 3 participants after RYGB, 1 after AGB, and 1 after MWL.

conclusionsAt similar weight loss and glycemic improvement, the greatest alteration in gut microbiota occurred after RYGB with an increase in the potentially beneficial bacterium, F. prausnitzii. Gut microbial diversity tended to decrease after AGB and increase after RYGB and MWL. Future studies are needed to determine the impact and durability of gut microbial changes over time and their role in long-term metabolic improvement after bariatric surgery in adults with type 2 diabetes. CLINICAL

trial registrationNCTDK089557- ClinicalTrials.gov.

Indexed as

AdultBacteriaBacterial Typing TechniquesBariatric SurgeryBiodiversityBlood GlucoseDiabetes Mellitus, Type 2FecesFemaleGastric BypassGastrointestinal MicrobiomeGastroplastyHumansMiddle AgedObesityObesity, MorbidBlood GlucoseRNA, Ribosomal, 16SDiabetesGastric bandGastric bypassGut microbiomeObesityRandomized controlled trial

Identifiers

PMID31256356
OpenAlexW2955245188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.