ArticleInternational orthopaedics2019
Altered seric levels of albumin, sodium and parathyroid hormone may predict early mortality following hip fracture surgery in elderly.
Article in International orthopaedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of preoperative predictors for early mortality following hip fracture surgery.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Nutrition-related clinical laboratory indicators in perioperative management of geriatric hip fractures: a narrative review from risk stratification to precision intervention.Frontiers in nutrition · 2026Review
- Investigation of the Medium- and Long-Term Results of a Pioneering Method in the Treatment of Geriatric Intertrochanteric Femur Fractures: Osteosynthesis Using the WALANT Technique.Journal of clinical medicine · 2025Article
- Preoperative identification of low-risk patients for major complications after acute hip fracture surgery in geriatric patients: an observational cohort study.BMC musculoskeletal disorders · 2025Observational
- The impact of biological age and age acceleration on 1-year mortality rates in elderly hip fracture patients: a prospective cohort study.Archives of osteoporosis · 2025Article
- Elevated albumin: a protective factor against mortality in geriatric hip fracture patients.Journal of orthopaedic surgery and research · 2025Article
- Association between markers of inflammation and outcomes after hip fracture surgery: analysis of routinely collected electronic healthcare data.BMC geriatrics · 2025Article
- Article
- Risk Factors for 30-Days Mortality After Proximal Femoral Fracture Surgery, a Cohort Study.Clinical interventions in aging · 2024Article
- Correlation between admission hypoalbuminemia and postoperative urinary tract infections in elderly hip fracture patients.Journal of orthopaedic surgery and research · 2023Observational
- Article
- Comparison of Prognostic Value of 10 Biochemical Indices at Admission for Prediction Postoperative Myocardial Injury and Hospital Mortality in Patients with Osteoporotic Hip Fracture.Journal of clinical medicine · 2022Article
- The role of routine postoperative laboratory tests following hip hemiarthroplasty for an elderly femoral neck fracture.BMC musculoskeletal disorders · 2021Article
- Rapid preoperative predicting tools for 1-year mortality and walking ability of Asian elderly femoral neck fracture patients who planned for hip arthroplasty.Journal of orthopaedic surgery and research · 2021Article
- The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture.Geriatric orthopaedic surgery & rehabilitation · 2020Article
- HYPOALBUMINEMIA IN MICROSURGICAL FLAPS OF THE MUSCULOSKELETAL APPARATUS.Acta ortopedica brasileiraArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse a wide set of routine laboratory parameters at admission to predict mortality within 30 post-operative days in elderly patients with hip fracture, as well as calculate the critical values of those biomarkers.
methodData of 994 patients older than 65 years with hip fracture were analysed of which 89 (8.2%) died within 30 post-operative days. Variables described in the literature with potential influence on early mortality were collected, including demographics, fracture type, American Society of Anesthesiologists score, Charlson's comorbidity index and pre-operative Hodkinson's mental test and the Katz index for activities of daily living. In addition, an exhaustive collection of biomarkers from routine blood testing at admission was performed. Critical levels of biomarkers were calculated by the method of area under ROC curve.
resultsAt admission, early mortality group had significantly higher Charlson's index (p = 0.001) and lower the Katz index (p = 0.001). The surgical delay also was significantly longer in that group (p = 0.001). In univariate analyses, serum concentration at admission of total protein (p = 0.004), albumin (p = 0.001), sodium (p = 0.001), and parathyroid hormone (PTH) (p = 0.001) were significantly different between both groups. In multivariate analysis, serum albumin < 2.9 g/dL (p = 0.013), sodium < 127 mEq/L (p = 0.035) and PTH > 65 pg/mL (p = 0.005) were predictors of early mortality. The three biomarkers together accounted for 67% of the variability in early mortality.
conclusionThe association of altered levels at admission of serum concentration of albumin, sodium and PTH was predictor of early mortality following hip fracture surgery in elderly patients.
Indexed as
Identifiers
31256198What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.