ArticleJournal of Alzheimer's disease : JAD2019
Sex Differences in Associations of Cognitive Function with Perceptions of Pain in Older Adults.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Senior WISE intervention: Gender differences in bodily pain and trait anxiety.Archives of psychiatric nursing · 2021Trial
- Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound.APL bioengineering · 2025Article
- Gender Differences in Pain Threshold, Unpleasantness, and Descending Pain Modulatory Activation Across the Adult Life Span: A Cross Sectional Study.The journal of pain · 2024Article
- Pain and Associated Factors in Nursing Home Residents.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Psychophysics of Pain: A Methodological Introduction.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- Brain responses to painful electrical stimuli and cognitive tasks interact in the precuneus, posterior cingulate cortex, and inferior parietal cortex and do not vary across the menstrual cycle.Brain and behavior · 2022Article
- Treating the most vulnerable: A discursive review of experimental pain in Alzheimer's disease.Nursing open · 2022Review
- The Relationship Between Pain, Function, Behavioral, and Psychological Symptoms of Dementia and Quality of Life.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022Article
- Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Chronic Pain in the Elderly: Mechanisms and Perspectives.Frontiers in human neuroscience · 2022Review
- Promoting successful participation of people living with Alzheimer's disease and related dementias in pain-related neuroimaging research studies.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Population-Focused Approaches for Proactive Chronic Pain Management in Older Adults.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- Narrative Review of Sensory Changes as a Biomarker for Alzheimer's Disease.Biological research for nursing · 2021Review
- Policy Issues Affecting Nursing Pain Management: A New Decade of Hope.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- Policy Implications for Pain in Advanced Alzheimer's Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Article
- A Paradigm Shift for Movement-based Pain Assessment in Older Adults: Practice, Policy and Regulatory Drivers.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Review
- Could Altered Evoked Pain Responsiveness Be a Phenotypic Biomarker for Alzheimer's Disease Risk? A Cross-Sectional Analysis of Cognitively Healthy Individuals.Journal of Alzheimer's disease : JAD · 2021Article
- Cognitive Functioning, Life Satisfaction, and Their Relationship with the Financial Attitudes of Older Individuals Who Participate in an Active Aging Program.Behavioral sciences (Basel, Switzerland) · 2020Article
- Relation Between Neck Pain and Modic Changes in Cervical Spondylotic Myelopathy.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundSex differences in pain have been shown to exist in older adults with normal cognition and people with Alzheimer's disease. It is unknown if sex differences in pain in older adults exist in a range of communicative older adults with varying cognitive ability from no impairment to moderately severe cognitive impairment.
objectiveThis study proposes to compare the association between psychophysical responses to experimental thermal pain between males and females to determine if sex differences in pain exist across the cognitive spectrum.
methodsWe conducted a secondary analysis of data from an age- and sex-matched between-groups cross-sectional study examining the psychophysical response to contact heat in people with and without dementia.
resultsMedian age of males (n = 38) and females (n = 38) was 73 (range: 68-87) with similar distributions of Mini-Mental State Examination (MMSE) scores (range: 11-30). Findings revealed inverse statistically significant associations with the threshold temperature of warmth (females: r = -0.41, p = 0.010; males: r = -0.33, p = 0.044). There was an apparent divergent pattern of MMSE associations with unpleasantness ratings between the groups. At the moderate pain threshold, that difference became statistically significant (p = 0.033). Females demonstrated a positive association of MMSE with unpleasantness (r = 0.30, p = 0.072), while males demonstrated an inverse association at that respective threshold (r = -0.20, p = 0.221).
conclusionsBetween-group findings suggest that patterns of responses to thermal stimulus intensity may differ between males and females with worsening cognition with females reporting significantly less unpleasantness with the percept of moderate pain and males reporting significantly higher unpleasantness with moderate pain perception.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.