ArticleJournal of Alzheimer's disease : JAD2019
Vascular Health is Associated with Amyloid-β in Cognitively Normal Older Adults.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review.The Journal of physiology · 2026Pooled it
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- A Narrative Review Evaluating Diet and Exercise as Complementary Medicine for the Management of Alzheimer's Disease.Nutrients · 2025Review
- Cerebrovascular function and its association with systemic artery function and stiffness in older adults with and without mild cognitive impairment.European journal of applied physiology · 2022Article
- Cerebrovascular response to exercise interacts with individual genotype and amyloid-beta deposition to influence response inhibition with aging.Neurobiology of aging · 2022Article
- Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Heat therapy: possible benefits for cognitive function and the aging brain.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults.Nutrients · 2020Article
- AQP4 Drives Gliotic Changes in an APPPS1 Mouse Model of Alzheimer's Disease.Current health sciences journalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundVascular health is closely related to Alzheimer's disease (AD). Vascular function measured by flow mediated dilation (FMD) or pulsatility index (PI) can be used as marker of peripheral and central vascular health but is poorly characterized in those at risk for AD.
objectiveTo assess the relationship of peripheral and central vascular function with amyloid-β (Aβ) and white matter lesion burden among cognitively normal older adults.
methodsWe enrolled participants 65 years of age and older. Using Doppler ultrasound, we assessed brachial artery FMD, and middle cerebral artery (PI). Global Aβ burden, quantified using [18F] Florbetapir PET imaging, and white matter lesion volume (WML) were used as measures of AD pathology and vascular brain injury.
resultsAfter adjusting for age and cardiovascular risk factors, the data (n = 83) showed a negative association between FMD and Aβ burden (β= -0.03, p < 0.001). FMD at a cut-off of 4.45% had 88% specificity and 75% sensitivity to elevated Aβ (AUC = 0.86, 95% CI: 0.77-0.95). FMD was not related to WML volume (p = 0.8), and PI was unrelated to Aβ burden or WML volume (0 > 0.4).
conclusionsAmong cognitively normal older adults, blunted peripheral vascular function, as measured by brachial artery FMD, is associated with Aβ burden. These findings provide support for further exploration into the pathophysiological relationship of vascular health and AD risk as measured by Aβ.
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