Evidence map›Paper›PMID 31256066›Full record

ArticleJournal of pediatric endocrinology & metabolism : JPEM2019

Cushing disease in a patient with nonbullous congenital ichthyosiform erythroderma: lessons in avoiding glucocorticoids in ichthyosis.

Iris R Hartley, Julia Costa Beber Nunes, Maya Lodish, Constantine A Stratakis

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric endocrinology & metabolism : JPEM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Iris R HartleyEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Inter-Institute Endocrinology Fellowship Program, Bethesda, MD, USA.
Julia Costa Beber NunesFederal University of Parana, Curitiba, Brazil.
Maya LodishEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH and Section on Endocrinology and Genetics (SEGEN), NICHD, NIH, Bethesda, MD, USA.
Constantine A StratakisEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH and Section on Endocrinology and Genetics (SEGEN), NICHD, NIH, Bethesda, MD, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversidade Federal do Paraná · BR

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
Molecular Genetics Of Adrenocortical Tumors And Related DisordersZIAHD000642 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2009 to 2011
$9.6M
Molecular Genetics Of Adrenocortical Tumors And Related DisordersZ01HD000642 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 1998 to 2008
$4.7M
Intramural NIH HHS Z01 HD000642Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000642Intramural NIH HHS ZIA HD008920
6 · The paper itself

Abstract

Nonbullous congenital ichthyosis erythroderma (CIE) is an autosomal recessive disorder of ineffective keratinization. We present a unique case of a 16-year-old female with CIE who developed Cushing disease (CD) at age 13 with concomitant worsening of her skin disease. After transsphenoidal resection of her pituitary adenoma, she had both resolution of her Cushing symptoms and significantly milder skin manifestations of her CIE. To the best of our knowledge, this is the first reported case of a patient with both CD and CIE, one that is important in demonstrating the role of glucocorticoids in this disorder.

Indexed as

AdolescentFemaleGlucocorticoidsHumansHydrocortisoneIchthyosiform Erythroderma, CongenitalPituitary ACTH HypersecretionPrognosisWithholding TreatmentGlucocorticoidsHydrocortisoneCushing diseaseCushing syndromenonbullous congenital ichthyosis erythroderma

Identifiers

PMID31256066
PMCPMC7427504
OpenAlexW2955647738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.