Evidence map›Paper›PMID 31256005›Full record

ArticleJournal of medical ethics2019

Moral uncertainty and the farming of human-pig chimeras.

Julian Koplin, Dominic Wilkinson

Abstract read
In one paragraph

Article in Journal of medical ethics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Emerging moral status issues.Monash bioethics review · 2020
    Review
  8. Article
  9. Animals in Moral Limbo: How Literary Pigs May Help Lab-Generated Ones.Animals : an open access journal from MDPI · 2020
    Review
  10. Moral Limits of Brain Organoid Research.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Julian KoplinMurdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0002-2752-7334
Dominic WilkinsonMurdoch Children's Research Institute, Parkville, Victoria, Australia.

Funding

Wellcome Trust
6 · The paper itself

Abstract

It may soon be possible to generate human organs inside of human-pig chimeras via a process called interspecies blastocyst complementation. This paper discusses what arguably the central ethical concern is raised by this potential source of transplantable organs: that farming human-pig chimeras for their organs risks perpetrating a serious moral wrong because the moral status of human-pig chimeras is uncertain, and potentially significant. Those who raise this concern usually take it to be unique to the creation of chimeric animals with 'humanised' brains. In this paper, we show how that the same style of argument can be used to critique current uses of non-chimeric pigs in agriculture. This reveals an important tension between two common moral views: that farming human-pig chimeras for their organs is ethically concerning, and that farming non-chimeric pigs for food or research is ethically benign. At least one of these views stands in need of revision.

Indexed as

ChimeraMoralsSwineUncertaintyAnimalsHumanschimerasmoral statusstem cell researchtransplantation

Identifiers

PMID31256005
PMCPMC6691869

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.