Evidence map›Paper›PMID 31255951›Full record

ArticlePsychoneuroendocrinology2019

Co-twin relationship quality as a moderator of genetic and environmental factors on urinary cortisol levels among adult twins.

Joseph A Schwartz, Scott Jessick, Jessica L Calvi, Douglas A Granger

Abstract readTwin Study

In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph A SchwartzSchool of Criminology and Criminal Justice, University of Nebraska at Omaha, Omaha, NE, 68182-0149, USA. Electronic address: jaschwartz@unomaha.edu.

Scott JessickSchool of Criminology and Criminal Justice, University of Nebraska at Omaha, Omaha, NE, 68182-0149, USA.

Jessica L CalviSalivary Bioscience Laboratory, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.

Douglas A GrangerSalivary Bioscience Laboratory, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, 21218, USA; School of Nursing, The Johns Hopkins University, Baltimore, MD, 21218, USA; School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California, Irvine, CA, 92697-7085, USA.

Funding

STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015

$50.6M

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011

$43.4M

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016

$32.2M

WIHS INTENSIVE PHARMACOKINETIC STUDY (IPS)M01RR023942 · NCRR · GEORGETOWN UNIVERSITY · PI FEDEROFF, HOWARD J. · 2007 to 2009

$6.9M

NCATS NIH HHS UL1 TR000427NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR023942NIA NIH HHS P01 AG020166

6 · The paper itself

Abstract

Previous research has indicated that genetic and environmental factors shape physiological activity. Cortisol levels, in particular, have received significant attention, with studies indicating substantive heritability estimates across various sampling techniques. A related line of research has indicated that genetic and environmental factors that explain variability in cortisol levels may vary across context and experiences by way of gene-environment interactions (G × Es). Despite these findings, a limited number of studies have examined the extent to which interpersonal relationships may operate as a moderator. The current study focused on co-twin relationship quality as a source of moderation, as twins are more likely to have contact with one another and to form close, interpersonal relationships with their co-twin relative to singleton siblings. Using a sample of 298 adult twins from the National Survey of Midlife Development in the United States (MIDUS), we examined the extent to which genetic and environmental factors that explain variability in urinary cortisol levels varied across levels of co-twin relationship quality. The heritability of cortisol levels was greater and nonshared environmental influences were lower at greater levels of relationship quality. These findings suggest that the heritability of cortisol may vary across context, and positive relationships with others may moderate such factors.

Indexed as

Sibling RelationsAdultEnvironmentFemaleGene-Environment InteractionHumansHydrocortisoneInterpersonal RelationsMaleMiddle AgedSiblingsSurveys and QuestionnairesTwinsHydrocortisoneGene-environment interactionInterpersonal relationshipsUrinary cortisol

Identifiers

PMID31255951

DOI10.1016/j.psyneuen.2019.06.002

PMCPMC9380901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.