Evidence map›Paper›PMID 31255727›Full record

ArticleNeuroscience letters2019

Aging and HIV-1 alter the function of specific K

Lihua Chen, Christina E Khodr, Lena Al-Harthi, Xiu-T Hu

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Astrocytes, HIV and the Glymphatic System: A Disease of Disrupted Waste Management?Frontiers in cellular and infection microbiology · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lihua ChenDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States.
Christina E KhodrDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States.
Lena Al-HarthiDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States.
Xiu-T HuDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, 60612, United States. Electronic address: xiu-ti_hu@rush.edu.
Rush University Medical Center · US

Funding

Interplay between neuroprotective pathways, HIV, and astrocytesR01NS060632 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI AL-HARTHI, LENA · 2008 to 2018
$4.9M
Interactive effects of Meth, HIV and cART on astrocyte/neuron functionR01DA044552 · NIDA · RUSH UNIVERSITY MEDICAL CENTER · PI HU, XIU-TI · 2017 to 2021
$2.9M
Electrophysiological mechanisms of HIV-mediated neuropathogenesisR01NS084817 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI HU, XIU-TI · 2013 to 2017
$2.5M
mechanisms of HIV and drug abuse pathogenesis in CNSR01DA033966 · NIDA · RUSH UNIVERSITY MEDICAL CENTER · PI AL-HARTHI, LENA · 2012 to 2016
$1.7M
NIDA NIH HHS R01 DA033966NIDA NIH HHS R01 DA044552NINDS NIH HHS R01 NS060632NINDS NIH HHS R01 NS084817
6 · The paper itself

Abstract

The medial prefrontal cortex (mPFC) is a key regulator of neurocognition. The glutamatergic pyramidal neurons are the predominant component of neurons in the mPFC. Aging and HIV profoundly alter the structure and function of mPFC pyramidal neurons, including, but are not limited to, dysregulation of NMDA receptors and voltage-gated calcium channels. Here we assessed the impact of aging and in vivo HIV exposure on the functional activity (firing) of mPFC pyramidal neurons mediated by voltage-gated K

Indexed as

AgingAction PotentialsAnimalsHIV-1HIV InfectionsMalePotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedPrefrontal CortexPyramidal CellsRatsRNA, MessengerPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedRNA, MessengerAgingElectrophysiologyHIVK(+) channelMedial prefrontal cortexPyramidal neuron

Identifiers

PMID31255727
PMCPMC6693957
OpenAlexW2954535595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.