ArticleThe Knee2019
The influence of knee joint geometry and alignment on the tibiofemoral load distribution: A computational study.
Article in The Knee, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Returning to running after total knee arthroplasty: a systematic review and a novel multimodal protocol.Musculoskeletal surgery · 2025Pooled it
- The effect of modelling parameters in the development and validation of knee joint models on ligament mechanics: A systematic review.PloS one · 2022Pooled it
- Article
- Automatic extraction of 2D patellofemoral bone morphology and alignment measures from 3D models in a young adolescent population.Osteoarthritis imaging · 2026Article
- Effects of a neuromuscular exercise program on lower limb alignment and balance ability in individuals with genu varum and knee pain.Journal of exercise rehabilitation · 2026Article
- Personalized musculoskeletal models show that gait biofeedback alters knee cartilage contact mechanics in ACL-reconstructed subjects.Journal of biomechanics · 2026Article
- Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk.medRxiv : the preprint server for health sciences · 2026Article
- Meniscus Pathology in the Setting of Revision ACL Surgery: Unique Considerations.Current reviews in musculoskeletal medicine · 2026Review
- Altered gait strategies show inconsistent medial compartment unloading in varus medial knee osteoarthritis awaiting high tibial osteotomy.Clinical biomechanics (Bristol, Avon) · 2026Article
- A validated SSAM-FEA framework for the rat knee reproduces varus-induced contact redistribution in a meniscus-deficient setting.Frontiers in bioengineering and biotechnology · 2026Article
- Sex-specific differences in coronal knee alignment and CPAK distribution in an Austrian population.Archives of orthopaedic and trauma surgery · 2025Article
- Traumatic Onset of Medial Meniscus Posterior Root Tears Is Associated With Younger Age While Insidious Onset Is Associated With Chronic Overload and Bone Bruising.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Analysis of Genu Varum in Young Male Professional Soccer Players.Orthopaedic journal of sports medicine · 2025Article
- Is Native Joint Line More Accurately Restored with Robotic Assisted Total Knee Arthroplasty than with Conventional Instruments?Journal of orthopaedic case reports · 2025Article
- An increased medial proximal tibial angle of greater than 95 degrees after opening wedge high tibial osteotomy is not associated with deterioration of minimum 10-year clinical outcomes.Archives of orthopaedic and trauma surgery · 2024Article
- Impact of knee geometry on joint contact mechanics after meniscectomy.Scientific reports · 2024Article
- Effect of tibiofemoral alignment on simulated knee contact forces during gait in mechanically and kinematically aligned total knee arthroplasty patients.Scientific reports · 2024Article
- Knee-Loading Predictions with Neural Networks Improve Finite Element Modeling Classifications of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2024Article
- Deep learning enables accurate soft tissue tendon deformation estimation in vivo via ultrasound imaging.Scientific reports · 2024Article
- Use of patellofemoral digital twins for patellar tracking and treatment prediction: comparison of 3D models and contact detection algorithms.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundDeviations in knee joint geometry and alignment were previously related to an increased risk for knee OA. These were hypothesized to influence the load distribution over the articular cartilage. Therefore, this study evaluated the effect of altered knee joint geometry and alignment in the coronal and transverse plane on the medial-lateral load distribution and ligament strain using a musculoskeletal modeling approach.
methodsJoint kinematics during gait were measured in 15 healthy adults. Using different musculoskeletal models with altered geometry of the tibia plateau or knee joint malalignment in the coronal and transverse plane, the resulting muscle, ligament and contact forces were calculated. Next, the distribution of the load over the medial and lateral condyle was analyzed and compared to the reference loading distribution, with neutral geometry and alignment, using repeated-measures ANOVA and individual t-tests, with a Bonferroni-corrected alpha level.
resultsCoronal plane malalignment significantly affected the load distribution. Small changes in coronal tibial slope had less pronounced effects on the load distribution, but increased ligament strains. Transverse plane malalignment only minimally affected the load distribution.
conclusionCoronal plane knee malalignment affected knee loading, with increased varus alignment resulting in increased medial loading. This confirms a causal relation between coronal malalignment and increased medial compartment loading and suggests a potential role of aberrant coronal plane alignment on OA initiation. Altered coronal tibial slope induced increased ligament strains, potentially contributing to a cascade of knee laxity and subsequently more extreme knee malalignment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.