ReviewBioorganic & medicinal chemistry2019
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids.
Review in Bioorganic & medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 120 citations in OpenAlex.
- Artificial intelligence-driven discovery of coumarin-based therapeutics: Revolutionizing target identification and validation.Pharmaceutical science advances · 2026Review
- Coumarin-Based Hybrids: From Linear Photophysical Properties to Multiphoton Excitation Behavior.ACS physical chemistry Au · 2026Article
- Novel pyrazole-oxadiazole-chalcone/oxime hybrids as dual EGFR/VEGFR-2 inhibitors with promising anticancer potential: a comprehensive cytotoxicity evaluation, mechanistic insights and SAR analysis.Molecular diversity · 2026Article
- Is scaffold hopping possible in machine learning using the electronic-structure-informatics (ESI) descriptor set? an application to natural-product-based drug discovery of α-glucosidase inhibitors.Journal of cheminformatics · 2026Article
- Exploring the Potential of Coumarin as a Potent Antitubercular Agent.Mini reviews in medicinal chemistry · 2026Review
- Coumarin-Dithiocarbamate Derivatives as Biological Agents.International journal of molecular sciences · 2025Review
- Therapeutic potential of 3-acetyl coumarin against polycystic ovarian syndrome induced by letrozole using female rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Characterization of the Antiproliferative and Antimetastatic Properties ofInternational journal of molecular sciences · 2025Article
- Synergistic effects of doxorubicin and coumarin on colorectal cancer cell proliferation and EMT modulation:Annals of medicine and surgery (2012) · 2025Article
- In-silico identification and exploration of small molecule coumarin-1,2,3-triazole hybrids as potential EGFR inhibitors for targeting lung cancer.Molecular diversity · 2024Article
- Novel Coumarin-Nucleobase Hybrids with Potential Anticancer Activity: Synthesis, In Vitro Cell-Based Evaluation, and Molecular Docking.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Nanomaterial-Based Sensors for Coumarin Detection.ACS omega · 2024Review
- Coumarin/β-Cyclodextrin Inclusion Complexes Promote Acceleration and Improvement of Wound Healing.ACS applied materials & interfaces · 2024Article
- Latest developments in coumarin-based anticancer agents: mechanism of action and structure-activity relationship studies.RSC medicinal chemistry · 2024Review
- A comprehensive review on the potential of coumarin and related derivatives as multi-target therapeutic agents in the management of gynecological cancers.Frontiers in pharmacology · 2024Review
- The Study of Hypoglycemic Activity of 7-Terpenylcoumarins.Molecules (Basel, Switzerland) · 2022Article
- Recent Advances in Natural Product-Based Hybrids as Anti-Cancer Agents.Molecules (Basel, Switzerland) · 2022Review
- Recent advances in the development of active hybrid molecules in the treatment of cardiovascular diseases.Bioorganic & medicinal chemistry · 2022Review
- Synthesis and potent antimicrobial activity of novel coumarylthiazole α-aminophosphonates derivatives.Molecular diversity · 2022Article
- Cancer Cell Inhibiting Sea Cucumber (Nutrients · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery that has attracted substantial traction in the past few years. Naturally occurring scaffolds such as coumarins display a wide spectrum of pharmacological activities including anticancer, antibiotic, antidiabetic and others, by acting on multiple targets. In this view, various coumarin-based hybrids possessing diverse medicinal attributes were synthesized in the last five years by conjugating coumarin moiety with other therapeutic pharmacophores. The current review summarizes the recent development (2014 and onwards) of these pharmacologically active coumarin hybrids and demonstrates rationale behind their design, structure-activity relationships (SAR) and mechanistic studies performed on these hybrid molecules. This review will be beneficial for medicinal chemist and chemical biologist, and in general to the drug discovery community and will facilitate the synthesis and development of novel, potent coumarin hybrid molecules serving as lead molecules for the treatment of complex disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.