Evidence map›Paper›PMID 31255494›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2019

Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.

Oscar L Lopez, Yuefang Chang, Diane G Ives, Beth E Snitz, Annette L Fitzpatrick, Michelle C Carlson, Stephen R Rapp, Jeffrey D Williamson, Russell P Tracy, Steven T DeKosky and 1 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Antioxidants (Basel, Switzerland) · 2024
    Review
  7. Review
  8. Review
  9. Antioxidants (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Oscar L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: lopezol@upmc.edu.
Yuefang ChangDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Diane G IvesDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Beth E SnitzDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Annette L FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA.
Michelle C CarlsonDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Stephen R RappDepartment of Psychiatry and Behavioral Medicine, Wake Forest University, Winston-Salem, NC, USA.
Jeffrey D WilliamsonDepartment of Medicine and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University, Winston-Salem, NC, USA.
Russell P TracyDepartment of Pathology, University of Vermont, Colchester, VT, USA; Department of Biochemistry, University of Vermont, Colchester, VT, USA.
Steven T DeKoskyDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Lewis H KullerDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USWake Forest University · USJohns Hopkins University · USUniversity of Florida · USUniversity of Vermont · USUniversity of Washington · US

Funding

Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
GINKGO BILOBA PREVENTION TRIAL IN OLDER INDIVIDUALSU01AT000162 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 1999 to 2009
$34.7M
NCCIH NIH HHS U01 AT000162NIA NIH HHS P01 AG025204NIA NIH HHS P50 AG005133
6 · The paper itself

Abstract

introductionBoth high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects.

methodsWe examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age >75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment.

resultsIncreased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairment participants. DISCUSSION: There was an inverse association between Aβ1-42 and Aβ1-42/Aβ1-40 ratio to risk of dementia in CN participants. Cerebral and cardiovascular disease and renal function are important determinants of increased Aβ levels and must be considered in evaluations of relationship of plasma Aβ and subsequent risk of dementia.

Indexed as

AgedAged, 80 and overAmyloid beta-PeptidesBiomarkersDementiaFemaleGinkgo bilobaGinkgo ExtractHumansIncidenceLongitudinal StudiesMaleMemoryPlant ExtractsAmyloid beta-PeptidesBiomarkersGinkgo biloba extractGinkgo ExtractPlant ExtractsApolipoprotein-EAβ1-42Blood levelsDementiaEpidemiology

Identifiers

PMID31255494
PMCPMC7325728
OpenAlexW2955432533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.