Evidence map›Paper›PMID 31255364›Full record

ReviewBlood reviews2019

Benign ethnic neutropenia.

Suheil Albert Atallah-Yunes, Audrey Ready, Peter E Newburger

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Blood reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06908616 (The Prevalence of Ethnic Neutropenia in Neonates), which is not on this map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06908616 recruitingnot on this mapstarted 2024, after this paper: background citation

The Prevalence of Ethnic Neutropenia in Neonates

TypeobservationalSponsorKaplan Medical CenterRan2024 to 2027Enrolled1,000ConditionsNeutropenia (Low White Blood Cell Count)ArmsCord blood
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  15. Genetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment.The British journal of psychiatry : the journal of mental science · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Suheil Albert Atallah-YunesDepartment of Medicine, University of Massachusetts Medical School, Baystate Medical Center, Springfield, MA 01103, USA. Electronic address: Suheil-albert.atallah-yunesmd@baystatehealth.org.
Audrey ReadyDepartment of Medicine, University of Massachusetts Medical School, Baystate Medical Center, Springfield, MA 01103, USA.
Peter E NewburgerDepartments of Pediatrics and Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: peter.newburger@umassmed.edu.
Baystate Medical Center · USUniversity of Massachusetts Chan Medical School · US

Funding

Severe Chronic Neutropenia International RegistryR24AI049393 · NIAID · UNIVERSITY OF WASHINGTON · PI DALE, DAVID CHANDLER · 2004 to 2019
$10.6M
NIAID NIH HHS R24 AI049393
6 · The paper itself

Abstract

Benign ethnic neutropenia (BEN) is one of the most common causes of chronic neutropenia seen in individuals of African, Middle Eastern and West Indian descent, affecting many individuals worldwide. Despite its prevalence, many physicians are not familiar with this benign condition, resulting in unnecessary evaluation and testing for neutropenia in otherwise healthy individuals. Clinically, patients with BEN are at no increased risk of infection despite their neutropenia. Implications of this condition are highlighted in those patients receiving therapies that have a known side effect of neutropenia, most commonly chemotherapy agents. Studies have suggested that disparities in survival among those patients receiving chemotherapy between patients of European decent and African decent may be attributed to measured neutropenia in these populations, questioning whether BEN could be an influential factor. This review encompasses all aspects of benign ethnic neutropenia, providing information about this condition and helping to guide clinical decision-making as to when an aggressive work up and referral are indicated and when it is appropriate to monitor. Additionally, we review the role of genetic studies in identifying the genes related to BEN, summarize the theories that offer the most accepted mechanisms behind the condition, and address the importance of pursuing larger studies to assess the implication of BEN in oncology patients as well as patients taking neutropenia-causing medications.

Indexed as

EthnicityHumansNeutropeniaBenign ethnic neutropeniaDARC geneDuffy antigen

Identifiers

PMID31255364
PMCPMC6702066
OpenAlexW2951939515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.