Evidence map›Paper›PMID 31255351›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2020

Identifying metabolomic profiles of inflammatory diets in postmenopausal women.

Fred K Tabung, Liming Liang, Tianyi Huang, Raji Balasubramanian, Yibai Zhao, Paulette D Chandler, JoAnn E Manson, Elizabeth M Cespedes Feliciano, Kathleen M Hayden, Linda Van Horn and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  16. Plasma leptin level mirrors metabolome alterations in young adults.Metabolomics : Official journal of the Metabolomic Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Fred K TabungDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, 410 W 12th Avenue, Columbus, OH, 43210, USA; The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Institute, 410 W 12th Avenue, Columbus, OH, 43210, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA; Division of Women's Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. Electronic address: fred.tabung@osumc.edu.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Tianyi HuangChanning Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.
Raji BalasubramanianDepartment of Biostatistics and Epidemiology, University of Massachusetts-Amherst, 715 N Pleasant Street, Amherst, MA, 01003, USA.
Yibai ZhaoDepartment of Biostatistics and Epidemiology, University of Massachusetts-Amherst, 715 N Pleasant Street, Amherst, MA, 01003, USA.
Paulette D ChandlerDepartment of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA, 02115, USA.
JoAnn E MansonDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA, 02115, USA.
Elizabeth M Cespedes FelicianoDivision of Research, Kaiser Permanente Northern California, 2051 Franklin Street, Oakland, CA, 94612, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest School of Medicine, 475 Vine Street, Winston-Salem, NC, 27101, USA.
Linda Van HornDepartment of Preventive Medicine, Northwestern University, 680 N Lakeshore Dr, Chicago, IL, 60611, USA.
Clary B ClishBroad Institute of the Massachusetts Institute of Technology and Harvard University, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Edward L GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
Kathryn M RexrodeDivision of Women's Health, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA; Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA; Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USUniversity of Massachusetts Amherst · USBroad Institute · USHarvard University · USKaiser Permanente · USNorthwestern University · USWake Forest University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BATEMAN, JAMES R., CRAFT, SUZANNE · 2016 to 2020
$12.2M
Beyond Body Mass Index: Bringing Body Composition into Oncology PracticeK01CA226155 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI FELICIANO, ELIZABETH MARJORIE CESPEDES · 2018 to 2022
$894k
Elucidating Inflammatory and Metabolic Pathways in Obstructive Sleep Apnea DevelopmentK01HL143034 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUANG, TIANYI · 2018 to 2022
$885k
Pro-inflammatory and Hyper-insulinemic Dietary Patterns and Colorectal Cancer Risk: Role of the MetabolomeR00CA207736 · NCI · OHIO STATE UNIVERSITY · PI TABUNG, FRED KINYUY · 2018 to 2020
$747k
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
NCI NIH HHS K01 CA226155NCI NIH HHS K99 CA207736NCI NIH HHS P30 CA016058NCI NIH HHS R00 CA207736NCI NIH HHS U01 CA138962NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS K01 HL143034NIA NIH HHS P30 AG049638NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

backgroundWe previously showed that a food-based empirical dietary inflammatory pattern (EDIP) score is associated with circulating inflammatory biomarkers. Metabolomic profiling of inflammatory diets may therefore provide insights on mechanisms contributing to disease etiology and prognosis. We aimed to elucidate metabolites associated with inflammatory diets among postmenopausal women, utilizing a robust study design that incorporates independent discovery and validation datasets.

methodsThis baseline cross-sectional investigation evaluated associations between continuous EDIP scores calculated from food frequency questionnaires and 448 log-transformed plasma metabolites as outcomes in multivariable-adjusted linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Metabolite discovery was conducted among 1109 Women's Health Initiative (WHI) Hormone Therapy trial participants and results were replicated in an independent dataset of 810 WHI Observational Study participants. Secondary analyses were stratified by standard body mass index (BMI, kg/m

resultsAfter adjusting for energy intake, BMI, physical activity, and other confounding variables, 23 metabolites were significantly associated with EDIP score in the discovery dataset. Of these, the following ten were replicated: trigonelline, caffeine, acethylamino-6-amino-3-methyluracil, 7-methylxanthine, 1,7-dimethyluric acid, 3-methylxanthine, C18:3CE, glycine, associated with lower dietary inflammatory potential; whereas C52:3 triacylglycerol and linoleate associated with higher dietary inflammatory potential. Four of the ten were associated [glycine (inversely), caffeine, 1,7-dimethyluric acid, C52:3 triacylglycerol, (positively)], with C-reactive protein levels. In secondary analyses, associations showed differences by BMI category. Four metabolites, related to coffee/caffeine metabolism were inversely associated among normal weight women, and 83 metabolites associated with EDIP among overweight/obese women, including 40 (48%) that were also associated with C-reactive protein.

conclusionMetabolites associated with coffee/caffeine and lipid metabolism may reflect the inflammatory potential of diet. Potential differences by BMI and the linkage to disease outcomes, require further study.

Indexed as

MetabolomicsAgedDietHumansInflammationMiddle AgedNutrition AssessmentDietary patternsInflammatory dietsMetabolomicsPostmenopausal women

Identifiers

PMID31255351
PMCPMC6918009
OpenAlexW2952817961

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