Evidence map›Paper›PMID 31254486›Full record

ArticleEquine veterinary journal2020

Fasciola hepatica in UK horses.

A K Howell, F Malalana, N J Beesley, J E Hodgkinson, H Rhodes, M Sekiya, D Archer, H E Clough, P Gilmore, D J L Williams

Open access · hybridAbstract read
In one paragraph

Article in Equine veterinary journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. In Vitro Effects of Vanadate Erbium/Silver Oxide (ErVOVeterinary medicine and science · 2025
    Article
  4. Genetic characterization of Fasciola hepatica (Linnaeus, 1758) in cattle from Paraná, Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

A K HowellInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0002-1988-1376
F MalalanaInstitute of Veterinary Science, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0002-5773-9725
N J BeesleyInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
J E HodgkinsonInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
H RhodesInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
M SekiyaSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.
D ArcherInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
H E CloughInstitute of Psychology, Health and Society, University of Liverpool, Liverpool, UK.
P GilmoreLiverpool Veterinary Parasitology Diagnostics, University of Liverpool, Liverpool, UK.
D J L WilliamsInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0001-8186-7236
University of Liverpool · GBUniversity College Dublin · IE

Funding

Animal Welfare Foundation (AWF)
6 · The paper itself

Abstract

backgroundFasciola hepatica (liver fluke) affects grazing animals including horses but the extent to which it affects UK horses is unknown.

objectivesTo define how liver fluke affects the UK horse population. STUDY

designDescriptive, cross-sectional, observational study.

methodsAn F. hepatica excretory-secretory antibody detection ELISA with a diagnostic sensitivity of 71% and specificity of 97% was validated and used to analyse serum samples. An abattoir study was performed to determine prevalence. A case-control study of 269 horses compared fluke exposure between horses with liver disease and controls. Data on clinical signs and blood test results were collected for sero-positive horses. Genotyping of adult fluke was used to produce a multilocus genotype for each parasite.

resultsFour (2.2%) of 183 horses registered in the UK, sampled in the abattoir, had adult flukes in the liver, and the sero-prevalence of F. hepatica was estimated as 8.7%. In the case-control study, horses showing signs consistent with liver disease had significantly higher odds of testing positive for F. hepatica on ELISA than control horses. In 23 sero-positive horses, a range of non-specific clinical signs and blood test abnormalities was reported, with a third of the horses showing no signs. Genotypic analysis of liver flukes from horses provided evidence that these came from the same population as flukes from sheep and cattle. MAIN LIMITATIONS: Bias could have arisen in the prevalence and case-control studies due to convenience sampling methods, in particular the geographic origin of the horses. Only a small number of horses tested positive so the data on clinical signs are limited.

conclusionsExposure to liver fluke occurs frequently in horses and may be an under-recognised cause of liver disease. Flukes isolated from horses are from the same population as those found in ruminants. When designing and implementing parasite control plans, fluke should be considered, and horses should be tested if appropriate.

Indexed as

Fasciola hepaticaAnimalsCase-Control StudiesCattleCross-Sectional StudiesFascioliasisHorsesSheepUnited KingdomELISAFasciola hepaticahorsemicrosatellite

Identifiers

PMID31254486
PMCPMC7027485
OpenAlexW2954876971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.