Evidence map›Paper›PMID 31254461›Full record

ArticleAging2019

Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast.

Kyung-Mi Choi, Sorah Kim, Seahyun Kim, Hae Min Lee, Alaattin Kaya, Bok-Hwan Chun, Yong Kwon Lee, Tae-Sik Park, Cheol-Koo Lee, Seong-Il Eyun and 1 more

Open access · greenAbstract read
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Kyung-Mi ChoiCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Sorah KimCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Seahyun KimCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Hae Min LeeCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Alaattin KayaDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Bok-Hwan ChunCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Yong Kwon LeeDepartment of Culinary Art and Food Service Management, Yuhan University, Bucheon 422-749, Republic of Korea.
Tae-Sik ParkDepartment of Life Science, Gachon University, Sungnam, Republic of Korea.
Cheol-Koo LeeCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Seong-Il EyunDepartment of Life Science, Chung-Ang University, Seoul, Republic of Korea.
Byung Cheon LeeCollege of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Korea University · KRChung-Ang University · KRGachon University · KRYuhan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenously produced hydrogen sulfide was proposed to be an underlying mechanism of lifespan extension via methionine restriction. However, hydrogen sulfide regulation and its beneficial effects via methionine restriction remain elusive. Here, we identified the genes required to increase hydrogen sulfide production under methionine restriction condition using genome-wide high-throughput screening in yeast strains with single-gene deletions. Sulfate assimilation-related genes, such as

Indexed as

Gene Expression Regulation, FungalHydrogen SulfideMethionineReactive Oxygen SpeciesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSulfatesHydrogen SulfideMethionineReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsSulfateshigh-throughput genetic screeninghydrogen sulfidemethionine restrictionreactive oxygen speciessulfate assimilation

Identifiers

PMID31254461
PMCPMC6628990
OpenAlexW2953746445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.