ArticleJournal of neuro-oncology2019
Primary central nervous system tumor treatment and survival in the United States, 2004-2015.
Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05739500 (The Clinical Trial 01 to Evaluate the Effectiveness of MRI-based Computer Aided Diagnosis Software), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Trial 01 to Evaluate the Effectiveness of MRI-based Computer Aided Diagnosis Software (V1) for Glioma Segmentation, Gene Prediction and Tumor Grading
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Assessing the Impact of Neighborhood and Built Environment on Pediatric Perioperative Care: A Systematic Review of the Literature.Journal of pediatric surgery · 2024Pooled it
- Tumor treating fields plus temozolomide for newly diagnosed glioblastoma: a sub-group analysis of Korean patients in the EF-14 phase 3 trial.Journal of neuro-oncology · 2020Trial
- Ophiobolin A Induces an Apoptotic Transcriptional Signature and Modulates Redox Homeostasis in T98G and U118MG Glioblastoma Cells: A Machine Learning Approach.International journal of molecular sciences · 2026Article
- Survival of nervous system tumors in a Colombian population cancer registry.Journal of neuro-oncology · 2025Article
- Immunological Insights into Photodynamic Therapy of Glioblastoma Multiforme.Molecules (Basel, Switzerland) · 2025Review
- A novel cuproptosis-associated LncRNA model predicting prognostic and immunotherapy response for glioma.Discover oncology · 2025Article
- Ecdysteroid-Containing Squalenoylated Self-Assembling Nanoparticles Exert Tumor-Selective Sensitization to Reactive Oxygen Species (ROS)-Induced Oxidative Damage While Protecting Normal Cells: Implications for Selective Radiotherapy.Journal of medicinal chemistry · 2025Article
- A retrospective single-centre study on the histological profile of brain and spine tumours at a tertiary hospital in Ghana.Ghana medical journal · 2025Article
- The aggrephagy-related gene TUBA1B influences clinical outcomes in glioma patients by regulating the cell cycle.Frontiers in oncology · 2025Article
- Procedural volume is linearly associated with mortality, major complications, and readmissions in patients undergoing malignant brain tumor resection.Journal of neuro-oncology · 2024Article
- Racial/ethnic disparities in all-cause and cause-specific death among children with malignant central nervous system tumours: a registry-based cohort retrospective analysis.EClinicalMedicine · 2024Article
- Enhancing mitosis quantification and detection in meningiomas with computational digital pathology.Acta neuropathologica communications · 2024Article
- Risk factors for intraoperative blood loss in resection of intracranial meningioma: Analysis of 530 cases.PloS one · 2023Article
- Radiosensitization of calreticulin-overexpressing human glioma cell line by the polyphenolic acetate 7, 8-diacetoxy-4-methylcoumarin.Cancer reports (Hoboken, N.J.) · 2022Article
- Quality of Life after Surgical Treatment of Brain Tumors.Journal of clinical medicine · 2022Article
- Pediatric neurological cancer incidence and trends in the United States, 2000-2018.Cancer causes & control : CCC · 2022Article
- Intraoperative detection of human meningioma using a handheld visible resonance Raman analyzer.Lasers in medical science · 2022Article
- Hematological adverse events in the management of glioblastoma.Journal of neuro-oncology · 2022Article
- The cuproptosis-related signature associated with the tumor environment and prognosis of patients with glioma.Frontiers in immunology · 2022Article
- Evolving Use of fMRI in Medicare Beneficiaries.AJNR. American journal of neuroradiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionBrain tumor treatment and survival information is generally limited in large-scale cancer datasets. We provide a clinical investigation of current patterns of care and survival estimates for central nervous system (CNS) tumors treated in the United States.
methodsWe analyzed the National Cancer Database from 2004-2015 for all patients with diagnosis of primary CNS tumors. We describe patient demographics, treatment modality, and analyzed survival estimates.
results512,168 patient tumor records were examined. The most common histology was meningioma (43.6%), followed by glioblastoma (22.0%), and nerve sheath tumors (10.6%). Patients had a median age of 60 years, with a female (57.9%), white (85.0%), and non-Hispanic (87.8%) predominance. Tumors were reported as World Health Organization (WHO) grade I for 55.9% of the patients, grade II for 5.9%, grade III for 4.4%, grade IV for 24.3%, and grade unknown or not applicable for 9.4%. Overall, 56% underwent surgical procedures, 30.4% received radiation, and 20.6% received chemotherapy. Radiation plus chemotherapy and surgery was the most common treatment modality in high-grade tumors (40.5% in WHO grade III and 49.3% in WHO grade IV), while surgery only or watchful waiting was preferred in low-grade tumors. Older age, male gender, non-Hispanic origin, higher number of comorbidities, and lower socioeconomic status were identified as risk factors for mortality.
conclusionsOur analysis provides long-term survival estimates and initial treatment decisions for patients with CNS tumors in hospitals throughout the United States. Age, comorbidities, gender, ethnicity, and socioeconomic characteristics were determinants of survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.