SynthesisInfection2019
Prognostic factors of mortality after surgery in infective endocarditis: systematic review and meta-analysis.
Synthesis in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comparison of different antibiotic regimens for the treatment of infective endocarditis.The Cochrane database of systematic reviews · 2020Pooled it
- Early Mortality in Reoperative Cardiac Surgery: Determinants, Prediction, and Calibration.Diagnostics (Basel, Switzerland) · 2026Article
- Mitral valve abscess: echocardiographic imaging, microbiology, management, and outcomes.European heart journal. Imaging methods and practice · 2026Article
- The role of clinical frailty in predicting mortality following surgery for infective endocarditis.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Postoperative mortality in patients requiring home oxygen therapy: a nationwide hospital-based database study.Journal of anesthesia · 2025Article
- Clinical presentation, microbiological profile, and management challenges of infective endocarditis: a retrospective study from a high volume cardiac centre in Pakistan.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Patients with multivalvular infective endocarditis demonstrate adverse cardiac remodeling before surgery with increased postoperative mortality risk.Journal of thoracic disease · 2025Article
- Fewer Minor Modified Duke Criteria on Admission Are Associated with Worse 90-Day Mortality in Patients with Confirmed Infective Endocarditis.Journal of clinical medicine · 2025Article
- Infective endocarditis risk scores: a narrative review.Journal of thoracic disease · 2025Review
- Pathogenic spectrum of infective endocarditis and analysis of prognostic risk factors following surgical treatment in a tertiary hospital in China.BMC infectious diseases · 2024Article
- Perioperative risk stratification scores in infective endocarditis and its usefulness.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Features of infective endocarditis in a contemporary cohort of persons who inject drugs: a matched comparison analysis of long-term prognostic factors.Internal and emergency medicine · 2024Article
- Clinical Features and Mortality Rate of Infective Endocarditis in Intensive Care Unit: A Large-Scale Study and Literature Review.Anatolian journal of cardiology · 2024Review
- Risk scores' performance and their impact on operative decision-making in left-sided endocarditis: a cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Infective Endocarditis: Still More Challenges Than Convictions.Arquivos brasileiros de cardiologia · 2022Article
- Sex-Specific Risk Factors for Short- and Long-Term Outcomes after Surgery in Patients with Infective Endocarditis.Journal of clinical medicine · 2022Article
- Preoperative serum albumin: a promising indicator of early mortality after surgery for infective endocarditis.Annals of translational medicine · 2021Article
- Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery.BMC infectious diseases · 2020Article
- Bugs at the operating theatre in infective endocarditis: one step forward, still a long way to go.Journal of thoracic disease · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is a lack of consensus about which endocarditis-specific preoperative characteristics have an actual impact over postoperative mortality. Our objective was the identification and quantification of these factors.
methodsWe performed a systematic review of all the studies which reported factors related to in-hospital mortality after surgery for acute infective endocarditis, conducted according to PRISMA recommendations. A search string was constructed and applied on three different databases. Two investigators independently reviewed the retrieved references. Quality assessment was performed for identification of potential biases. All the variables that were included in at least two validated risk scores were meta-analyzed independently, and the pooled estimates were expressed as odds ratios (OR) with their confidence intervals (CI).
resultsThe final sample consisted on 16 studies, comprising a total of 7484 patients. The overall pooled OR were statistically significant (p < 0.05) for: age (OR 1.03, 95% CI 1.00-1.05), female sex (OR 1.56, 95% CI 1.35-1.81), urgent or emergency surgery (OR 2.39 95% CI 1.91-3.00), previous cardiac surgery (OR 2.19, 95% CI 1.84-2.61), NYHA ≥ III (OR 1.84, 95% CI 1.33-2.55), cardiogenic shock (OR 4.15, 95% CI 3.06-5.64), prosthetic valve (OR 1.98, 95% CI 1.68-2.33), multivalvular affection (OR 1.35, 95% CI 1.01-1.82), renal failure (OR 2.57, 95% CI 2.15-3.06), paravalvular abscess (OR 2.39, 95% CI 1.77-3.22) and S. aureus infection (OR 2.27, 95% CI 1.89-2.73).
conclusionsAfter a systematic review, we identified 11 preoperative factors related to an increased postoperative mortality. The meta-analysis of each of these factors showed a significant association with an increased in-hospital mortality after surgery for active infective endocarditis. Graph summary of the Pooled Odds Ratios of the 11 preoperative factors analyzed after the systematic review and meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.