Evidence map›Paper›PMID 31254131›Full record

SynthesisLasers in medical science2019

Efficacy of laser treatment for onychomycotic nails: a systematic review and meta-analysis of prospective clinical trials.

Kelvin Yeung, Vinzent Kevin Ortner, Torben Martinussen, Uwe Paasch, Merete Haedersdal

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Lasers in medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. [Dermatomycoses: topical and systemic antifungal treatment].Dermatologie (Heidelberg, Germany) · 2024
    Review
  6. Review
  7. Review
  8. Fractional COLasers in surgery and medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Kelvin YeungDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Nielsine Nielsens Vej 17, entrance 9, second floor, 2400, Copenhagen, Denmark.
Vinzent Kevin OrtnerDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Nielsine Nielsens Vej 17, entrance 9, second floor, 2400, Copenhagen, Denmark. vinzent.kevin.ortner@regionh.dk.ORCID http://orcid.org/0000-0001-9708-6717
Torben MartinussenSection of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Uwe PaaschDepartment of Dermatology, Venereology, and Allergology, University of Leipzig, Leipzig, Germany.
Merete HaedersdalDepartment of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Nielsine Nielsens Vej 17, entrance 9, second floor, 2400, Copenhagen, Denmark.
University of Copenhagen · DKLeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laser therapy for onychomycosis is emerging but its efficacy remains unestablished. To examine current evidence on efficacy of laser treatment of onychomycosis. A systematic review and one-arm meta-analysis, including all prospective clinical trials, identified on PubMed, Cochrane Library, and EMBASE databases. Trials with participants as unit of analysis (UOA), n = 13, were analyzed separately from trials with nails as UOA, n = 7. Summary proportions and 95% confidence intervals (95% CI) were calculated. Outcomes were mycological cure, clinical improvement, or complete cure. Twenty-two prospective trials (four randomized controlled trials and 18 uncontrolled trials) with a total of 755 participants were analyzed. Summary proportions with 95% CI for participants as UOA were mycological cure 70.4%, 95% CI 52.2-83.8%; clinical improvement 67.2%, 95% CI 43.2-84.7%; and complete cure 7.2%, 95% CI 1.9-23.5%. High statistical heterogeneity was detected (mycological cure I

Indexed as

Laser TherapyHumansNailsOnychomycosisOutcome Assessment, Health CareProspective StudiesTreatment OutcomeEvidence-based medicineLaserMeta-analysisMycologyOnychologySystematic review

Identifiers

PMID31254131
OpenAlexW2956035768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.