Evidence map›Paper›PMID 31254098›Full record

SynthesisWorld journal of urology2020

Role of phosphodiesterase inhibitors in stent-related symptoms: a systematic review and meta-analysis.

Gopal Sharma, Aditya Prakash Sharma, Ravimohan S Mavuduru, Sudheer K Devana, Girdhar Singh Bora, Shrawan K Singh, Arup K Mandal

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Safety and efficacy of "on-demand" tramadol in patients with premature ejaculation: an updated meta-analysis.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
  2. Pharmacological treatment of bladder stent symptoms.Bladder (San Francisco, Calif.) · 2024
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gopal SharmaDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Aditya Prakash SharmaDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India. aditya.p.sharma@gmail.com.ORCID http://orcid.org/0000-0003-3071-9916
Ravimohan S MavuduruDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Sudheer K DevanaDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Girdhar Singh BoraDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Shrawan K SinghDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Arup K MandalDepartment of Urology, Postgraduate Institute of Medical Education and Research, Advance Urology Centre, B Block, Level II, Nehru Hospital Building, Chandigarh, 160012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeStent-related symptoms are frequent following stent placement for various indications. Use of PDE inhibitors has expanded beyond their classical indication and has been tried in patients with stent-related symptoms. The systematic review was conducted to ascertain the efficacy of PDE inhibitors in ameliorating stent-related symptoms.

methodsWe performed systematic review and metanalysis on the use of PDE inhibitors for stent-related symptoms in patients who underwent stent placement for various reasons (postpercutaneous nephrolithotomy or ureterorenoscopy). We followed PRISMA guidelines while conducting this review and study protocol was registered with PROSPERO (CRD42019121781)

resultsThree studies with 280 participants were included in this review. There was considerable heterogeneity across all the outcome parameters assessed; thus, random-effect model was used for analysis. Comparison of PDE inhibitors with control arm revealed that PDE inhibitors were significantly more effective than placebo in all but one domain (Work performance) of the USSQ. On comparison with alfa blockers, PDE inhibitors were found to be equally effective for urinary symptoms, general health, and body pain parameters, but sexual health parameters improved significantly with PDE inhibitors.

conclusionPDE inhibitors can be considered an option for patients with stent-related symptoms especially in patients with sexual dysfunction. Due to various limitations of the studies included in this review, we recommend conducting further high-quality studies.

Indexed as

Nephrolithotomy, PercutaneousUreteroscopyHumansPhosphodiesterase InhibitorsPostoperative ComplicationsStentsPhosphodiesterase InhibitorsAlfa blockerPhosphodiesterase inhibitorPlaceboUreteral stent

Identifiers

PMID31254098
OpenAlexW2954035775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.