ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2019
Alpha-phase synchrony EEG training for multi-resistant chronic low back pain patients: an open-label pilot study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Closed-Loop Infraslow Brain-Computer Interface can Modulate Cortical Activity and Connectivity in Individuals With Chronic Painful Knee Osteoarthritis: A Secondary Analysis of a Randomized Placebo-Controlled Clinical Trial.Clinical EEG and neuroscience · 2025Trial
- Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial.Scientific reports · 2023Trial
- Alpha activity neuromodulation induced by individual alpha-based neurofeedback learning in ecological context: a double-blind randomized study.Scientific reports · 2021Trial
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- [Non-invasive neuromodulation for chronic pain : A review of eight current methods and the evidence].Schmerz (Berlin, Germany) · 2026Review
- Neuroplasticity-Based Approaches to Sensory Processing Alterations in Autism Spectrum Disorder.International journal of molecular sciences · 2025Review
- Parietal-specific activation reveals pain from inadequate levels of altitude acclimatization/ adaptation.PloS one · 2025Article
- Virtual embodiment training is associated with relative alpha power modulation.Frontiers in human neuroscience · 2025Article
- A Scoping Review of the Effect of EEG Neurofeedback on Pain Complaints in Adults with Chronic Pain.Journal of clinical medicine · 2024Article
- A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: a pilot study.Scientific reports · 2024Article
- Preoperative resting-state microstate as a marker for chronic pain after breast cancer surgery.Brain and behavior · 2023Article
- Self-regulation training for people with knee osteoarthritis: a protocol for a feasibility randomised control trial (MiNT trial).Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- The Analysis of Spontaneous Electroencephalogram (EEG) in Chronic Low Back Pain Patients Compared with Healthy Subjects.Medical journal of the Islamic Republic of Iran · 2023Article
- Infraslow Neurofeedback Training Alters Effective Connectivity in Individuals with Chronic Low Back Pain: A Secondary Analysis of a Pilot Randomized Placebo-Controlled Study.Brain sciences · 2022Article
- Neurofeedback Therapy for Sensory Over-Responsiveness-A Feasibility Study.Sensors (Basel, Switzerland) · 2022Article
- Low Back Pain Assessment Based on Alpha Oscillation Changes in Spontaneous Electroencephalogram (EEG).Neural plasticity · 2021Article
- Using EEG Alpha States to Understand Learning During Alpha Neurofeedback Training for Chronic Pain.Frontiers in neuroscience · 2020Article
- Self-Regulation of SMR Power Led to an Enhancement of Functional Connectivity of Somatomotor Cortices in Fibromyalgia Patients.Frontiers in neuroscience · 2020Article
- Abnormal alpha band power in the dynamic pain connectome is a marker of chronic pain with a neuropathic component.NeuroImage. Clinical · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeChronic low back pain (cLBP) affects a quarter of a population during its lifetime. The most severe cases include patients not responding to interventions such as 5-week-long in-hospital multi-disciplinary protocols. This document reports on a pilot study offering an alpha-phase synchronization (APS) brain rehabilitation intervention to a population of n = 16 multi-resistant cLBP patients.
methodsThe intervention consists of 20 sessions of highly controlled electroencephalography (EEG) APS operant conditioning (neurofeedback) paradigm delivered in the form of visual feedback. Visual analogue scale for pain, Dallas, Hamilton, and HAD were measured before, after, at 6-month and 12-month follow-up. Full-scalp EEG data were analyzed to study significant changes in the brain's electrical activity.
resultsThe intervention showed a great and lasting response of most measured clinical scales. The clinical improvement was lasting beyond the 6-month follow-up endpoints. The EEG data confirm that patients did control (intra-session trends) and learned to better control (intersession trends) their APS neuromarker resulting in (nonsignificant) baseline changes in their resting state activity. Last and most significantly, the alpha-phase concentration (APC) neuromarker, specific to phase rather than amplitude, was found to correlate significantly with the reduction in clinical symptoms in a typical dose-response effect.
conclusionThis first experiment highlights the role of the APC neuromarker in relation to the nucleus accumbens activity and its role on nociception and the chronicity of pain. This study suggests APC rehabilitation could be used clinically for the most severe cases of cLBP. Its excellent safety profile and availability as a home-use intervention makes it a potentially disruptive tool in the context of nonsteroidal anti-inflammatory drugs and opioid abuses. These slides can be retrieved under Electronic Supplementary Material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.