ArticleJournal of neurology2019
Cognitive reserve impacts on disability and cognitive deficits in acute stroke.
Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Role of cognitive reserve in ischemic stroke prognosis: A systematic review.Frontiers in neurology · 2023Pooled it
- Systematic review on post-stroke computerized cognitive training: Unveiling the impact of confounding factors.Frontiers in psychology · 2022Pooled it
- Comprehensive verbal fluency features predict executive function performance.Scientific reports · 2021Trial
- Association between Cognitive Function and Postoperative Stroke Following Off-Pump Coronary Artery Bypass Grafting.Journal of cardiovascular translational research · 2026Article
- High Serum Glial Fibrillary Acidic Protein and Low Serum Vitamin D Levels as Risk Factors for Cognitive Impairment in Ischemic Stroke Patients.Neurology international · 2026Article
- How covariate control can bias our insights into brain architecture and pathology.Scientific reports · 2026Article
- The XGBoost Model Versus the Logistic Regression Model Created Based on Serum Markers in Predicting the Risk of Post-Stroke Cognitive Impairment Following Acute Ischemic Stroke.Brain and behavior · 2026Article
- Cognitive Recovery After Poststroke Delirium (RECOVER): Protocol for a Longitudinal Multimodal Study on Cognitive Assessment in Patients With Stroke.JMIR research protocols · 2026Article
- The post-ABI effect-long-term impact of aging on participation after acquired brain injury.Journal of neurology · 2025Observational
- Action Observation Training for Upper Limb Stroke Rehabilitation: A Pilot Study on the Role of Attention.Journal of clinical medicine · 2025Article
- The challenge of long-term stroke outcome prediction and how statistical correlates do not imply predictive value.Brain communications · 2025Article
- Brain health operationalized as brain parenchymal fraction impacts stroke severity both in acute phase and 3 months post stroke.Brain communications · 2025Article
- Post-stroke cognitive impairment: More than a lesion-symptom model.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Connectomic stroke lesion measures provide no benefit over basic spatial lesion features in the prognosis of global stroke outcome measures.Brain communications · 2025Article
- Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients.Frontiers in aging neuroscience · 2025Article
- Application of Multidomain Cognitive Training in a Tele-Neurorehabilitation Setting for Treatment of Post-Stroke Cognitive Disorders.Brain sciences · 2024Article
- The Role of Cognitive Reserve in Post-Stroke Rehabilitation Outcomes: A Systematic Review.Brain sciences · 2024Review
- Improving diagnostic accuracy of the Montreal Cognitive Assessment to identify post-stroke cognitive impairment.Scientific reports · 2024Observational
- Cognitive reserve modulates mental health in adulthood.Aging clinical and experimental research · 2024Article
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveAlthough post-stroke cognitive deficit can significantly limit patient independence and social re-integration, clinical routine predictors for this condition are lacking. 'Cognitive reserve' limits the detrimental effects of slowly developing neurodegeneration. We aimed to determine whether comparable effects also exist in acute stroke. Using 'years of education' as a proxy, we investigated whether cognitive reserve beneficially influences cognitive performance and disability after stroke, whilst controlling for age and lesion size as measure of stroke pathology.
methodsWithin the first week of ischemic right hemisphere stroke, 36 patients were assessed for alertness, working memory, executive functions, spatial neglect, global cognition and motor deficit at 4.9 ± 2.1 days post-stroke, in addition to routine clinical tests (NIH Stroke Scale, modified Rankin Scale on admission < 24 h post-stroke and at discharge 9.5 ± 4.7 days post-stroke). The impact of education was assessed using partial correlation analysis adjusted for lesion size, age, and the time interval between stroke and assessment. To validate our results, we compared groups with similar age and lesion load, but different education levels.
resultsIn the acute stroke phase, years of education predicted both severity of education independent (alertness) and education dependent (working memory, executive functions, global cognition) cognitive deficits and disability (modified Rankin Scale). Spatial neglect seemed to be independent.
interpretationProxies of cognitive reserve should be considered in stroke research as early as in the acute stroke phase. Cognitive reserve contributes to inter-individual variability in the initial severity of cognitive deficits and disability in acute stroke, and may suggest individualised rehabilitation strategies.
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