ReviewCellular and molecular life sciences : CMLS2019
Mechanisms regulating mammalian spermatogenesis and fertility recovery following germ cell depletion.
Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- JMJD3 Deficiency Alters H3K27me3 Landscapes and Adhesion-Related Transcriptional Programs in Aged Spermatogonia.Molecular reproduction and development · 2026Article
- Restoration of spermatogenesis is dependent on activation of a SPRY4-ERK checkpoint following germline stem cell damage†.Biology of reproduction · 2026Article
- IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shorter interval between consecutive testicular sperm aspirations and clinical pregnancy after intracytoplasmic sperm injection in obstructive azoospermia: a retrospective cohort study.Translational andrology and urology · 2026Article
- The effects of polysaccharides fromFrontiers in veterinary science · 2026Article
- Spermatogonial Stem Cells in Domestic Animals: Current Insights and Future Directions with a Focus on Dogs.Veterinary sciences · 2025Review
- Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage.bioRxiv : the preprint server for biology · 2025Article
- Dysregulation of N-glycosylation byInternational journal of biological sciences · 2025Article
- Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence.Frontiers in oncology · 2025Review
- Essential Regulation of Spermatogonial Stem Cell Fate Decisions and Male Fertility by APBB1 via Interaction with KAT5 and GDF15 in Humans and Mice.Research (Washington, D.C.) · 2025Article
- Protective Role of Sphingosine-1-Phosphate During Radiation-Induced Testicular Injury.Antioxidants (Basel, Switzerland) · 2024Review
- Functionally redundant roles of ID family proteins in spermatogonial stem cells.Stem cell reports · 2024Article
- Article
- Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.eLife · 2024Article
- Identification of quiescent FOXC2eLife · 2023Article
- Notch pathway is required for protection against heat stress in spermatogonial stem cells in medaka.Fish physiology and biochemistry · 2023Article
- The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells.International journal of molecular sciences · 2023Review
- Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer.Current issues in molecular biology · 2023Article
- Article
- Defining Gene Function in Spermatogonial Stem Cells Through Conditional Knockout Approaches.Methods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Mammalian spermatogenesis is a highly complex multi-step process sustained by a population of mitotic germ cells with self-renewal potential known as spermatogonial stem cells (SSCs). The maintenance and regulation of SSC function are strictly dependent on a supportive niche that is composed of multiple cell types. A detailed appreciation of the molecular mechanisms underpinning SSC activity and fate is of fundamental importance for spermatogenesis and male fertility. However, different models of SSC identity and spermatogonial hierarchy have been proposed and recent studies indicate that cell populations supporting steady-state germline maintenance and regeneration following damage are distinct. Importantly, dynamic changes in niche properties may underlie the fate plasticity of spermatogonia evident during testis regeneration. While formation of spermatogenic colonies in germ-cell-depleted testis upon transplantation is a standard assay for SSCs, differentiation-primed spermatogonial fractions have transplantation potential and this assay provides readout of regenerative rather than steady-state stem cell capacity. The characterisation of spermatogonial populations with regenerative capacity is essential for the development of clinical applications aimed at restoring fertility in individuals following germline depletion by genotoxic treatments. This review will discuss regulatory mechanisms of SSCs in homeostatic and regenerative testis and the conservation of these mechanisms between rodent models and man.
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Registered trials
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