ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2019
Identification of a candidate gene for a QTL for spikelet number per spike on wheat chromosome arm 7AL by high-resolution genetic mapping.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Post-Translational Control of TaFT1 by WAPO1 Ubiquitination Shapes Spike Architecture and Yield in Wheat.Plant biotechnology journal · 2026Article
- Regulation of spikelet number during wheat spike development.bioRxiv : the preprint server for biology · 2026Article
- Investigations into genetic control of six spike traits with a focus on breeding for terminal heat stress tolerance in common wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- High resolution mapping of agro-morphological and grain traits in bread wheat using SNP-based QTL analysis.PloS one · 2026Article
- Fine tuning wheat heading time through genome editing of transcription factor binding sites in Ppd-1 gene promoter.Scientific reports · 2025Article
- Wheat Tiller -1 (WT-1), a GRAS domain encoding gene, controls both tillering and spikelet number per spike in wheat.Plant molecular biology · 2025Article
- Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development.Genome biology · 2025Article
- Repeated chip analysis for reducing the effect of genotyping errors on gene mapping for two recombinant inbred line populations in wheat (Triticum aestivum L.).BMC plant biology · 2025Article
- Large-scale identification and association analysis of wheat grain weight genes using rice orthologs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification of robust yield quantitative trait loci derived from cultivated emmer for durum wheat improvement.The plant genome · 2025Article
- Genomic signals of ecogeographic adaptation in a wild relative are associated with improved wheat performance under drought stress.Genome biology · 2025Article
- Testing the potential of zebularine to induce heritable changes in crop growth and development.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Natural alleles of LEAFY and WAPO1 interact to regulate spikelet number per spike in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Identification and fine mapping of a QTL-rich region for yield- and quality-related traits on chromosome 4BS in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat.Development (Cambridge, England) · 2024Article
- Identification, validation and candidate gene analysis of major QTL for Supernumerary spikelets in wheat.BMC genomics · 2024Article
- Genome-wide association study and genomic selection of spike-related traits in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- GWAS in a Collection of Bulgarian Old and Modern Bread Wheat Accessions Uncovers Novel Genomic Loci for Grain Protein Content and Thousand Kernel Weight.Plants (Basel, Switzerland) · 2024Article
- A co-located QTL for seven spike architecture-related traits shows promising breeding use potential in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A Catalog ofPlants (Basel, Switzerland) · 2024Article
27 more citing papers are in PubMed but not listed here.
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15 authors.
Funding
Abstract
key messageA high-resolution genetic map combined with haplotype analyses identified a wheat ortholog of rice gene APO1 as the best candidate gene for a 7AL locus affecting spikelet number per spike. A better understanding of the genes controlling differences in wheat grain yield components can accelerate the improvements required to satisfy future food demands. In this study, we identified a promising candidate gene underlying a quantitative trait locus (QTL) on wheat chromosome arm 7AL regulating spikelet number per spike (SNS). We used large heterogeneous inbred families ( > 10,000 plants) from two crosses to map the 7AL QTL to an 87-kb region (674,019,191-674,106,327 bp, RefSeq v1.0) containing two complete and two partial genes. In this region, we found three major haplotypes that were designated as H1, H2 and H3. The H2 haplotype contributed the high-SNS allele in both H1 × H2 and H2 × H3 segregating populations. The ancestral H3 haplotype is frequent in wild emmer (48%) but rare (~ 1%) in cultivated wheats. By contrast, the H1 and H2 haplotypes became predominant in modern cultivated durum and common wheat, respectively. Among the four candidate genes, only TraesCS7A02G481600 showed a non-synonymous polymorphism that differentiated H2 from the other two haplotypes. This gene, designated here as WHEAT ORTHOLOG OF APO1 (WAPO1), is an ortholog of the rice gene ABERRANT PANICLE ORGANIZATION 1 (APO1), which affects spikelet number. Taken together, the high-resolution genetic map, the association between polymorphisms in the different mapping populations with differences in SNS, and the known role of orthologous genes in other grass species suggest that WAPO-A1 is the most likely candidate gene for the 7AL SNS QTL among the four genes identified in the candidate gene region.
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