SynthesisInternational orthopaedics2020
Candida periprosthetic infection of the hip: a systematic review of surgical treatments and clinical outcomes.
Synthesis in International orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Candida periprosthetic infection of the knee: a systematic review of surgical treatments and clinical outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Pooled it
- Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesGuideline
- Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Observational
- Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B.Journal of orthopaedic surgery and research · 2025Article
- Surgical procedures for the treatment of fungal periprosthetic infection following hip arthroplasty: a systematic scoping review.Annals of medicine and surgery (2012) · 2024Article
- The fate of fungal periprosthetic joint infection after total knee arthroplasty.International orthopaedics · 2023Article
- Revision of total knee arthroplasty with press-fit condylar SIGMA TC3-mobile bearing system and porous metaphyseal sleeves in type AORI type II and III bone defects. A long-term follow-up study.Acta bio-medica : Atenei Parmensis · 2023Article
- Voriconazole Admixed with PMMA-Impact on Mechanical Properties and Efficacy.Antibiotics (Basel, Switzerland) · 2023Article
- Periprosthetic Joint Infections Caused byJournal of fungi (Basel, Switzerland) · 2022Review
- Antifungal-Loaded Acrylic Bone Cement in the Treatment of Periprosthetic Hip and Knee Joint Infections: A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Revision arthroplasty with megaprosthesis after Girdlestone procedure for periprosthetic joint infection as an option in massive acetabular and femoral bone defects.Acta bio-medica : Atenei Parmensis · 2022Article
- Candida periprosthetic joint infections - risk factors and outcome between albicans and non-albicans strains.International orthopaedics · 2022Article
- Mixed bacterial-fungal infection following total hip arthroplasty: A case report.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Article
- Occurrence of Rare Pathogens at the Site of Periprosthetic Hip and Knee Joint Infections: A Retrospective, Single-Center Study.Antibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo produce a systematic analysis of types of treatment and outcomes of Candida hip periprosthetic joint infections and their correlation with specific pathogen species.
methodsDuring June 2018, a literature search of candida periprosthetic hip infection in PubMed, Scopus and Embase databases was performed according to the PRISMA (Preferred Reporting Item for Systematic Reviews and Meta-Analyses) guideline. Reviewers used Oxford level of evidence (LoE) and methodological index for non-randomised studies (MINORS) score. Modal distribution of surgical, pharmacological treatment and outcome along with the correlation between types of treatment and outcomes was calculated through the chi-square test.
resultsSeventy-nine cases were collected through 35 articles, identifying 81 pathogens. Candida albicans was the most common pathogen. Analysis of LoE reveals 26 LoE 5 (74.29%) and nine LoE 4 (26.71%). From nine LoE 4, ten patients (20.41%) underwent one-stage revision, 22 patients (44.90%) two-stage revision, 11 patients (22.45%) resection arthroplasty and six patients (12.24%) debridement with prosthesis retention. Global success was obtained in 31 cases (63.27%). Modal distribution revealed a preference for two-stage revision (22/49) and fluconazole as medical therapy (36/49). A significant difference was found between one-stage revision and resection arthroplasty (p = 0.031) or debridement (p = 0.003) and between two-stage revision and debridement (p = 0.013). No differences were found between Candida spp. in terms of the outcomes (p = 0.736). Methodological index showed a poor MINOR score.
conclusionsAnalysis of the literature suggests better clinical outcome with one- or two-stage revision than with resection arthroplasty or debridement, but the level of evidence is low.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.